SEGMENTAL ANEUPLOIDY AND THE GENETIC GROSS STRUCTURE OF THE DROSOPHILA GENOME (original) (raw)

Journal Article

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Present address: Department of Genetics, Institute of Animal Genetics, University of Edinburgh, Edinburgh 9, Scotland

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Present address: Division of Biology, California Institute of Technology, Pasadena, California 91109.

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Permanent address: Medical Research Council, Western General Hospital, Edinburgh 4, Scotland.

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Search for other works by this author on:

,

Department of Biology

, University of California at San Diego, La Jolla, California 92037 and Department of Genetics, University of Washington, Seattle, Washington 98105

Present address: Department of Biological Sciences; University of Maryland, Baltimore County; Baltimore, Maryland 21228

Search for other works by this author on:

... Show more

Received:

14 October 1971

• PDF
• Split View
• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Dan L Lindsley, L Sandler, Bruce S Baker, Adelaide T C Carpenter, R E Denell, Jeffrey C Hall, Patricia A Jacobs, George L Gabor Miklos, Brian K Davis, R C Gethmann, R W Hardy, A Hessler, Steven M Miller, Hiroshi Nozawa, Dilys M Parry, M Gould-Somero, SEGMENTAL ANEUPLOIDY AND THE GENETIC GROSS STRUCTURE OF THE DROSOPHILA GENOME, Genetics, Volume 71, Issue 1, 1 May 1972, Pages 157–184, https://doi.org/10.1093/genetics/71.1.157
Close

Navbar Search Filter Mobile Enter search term Search

ABSTRACT

By combining elements of two _Y_-autosome translocations with displaced autosomal breakpoints, it is possible to produce zygotes heterozygous for a deficiency for the region between the breakpoints, and also, as a complementary product, zygotes carrying a duplication for precisely the same region. A set of _Y_-autosome translocations with appropriately positioned breakpoints, therefore, can in principle be used to generate a non-overlapping set of deficiencies and duplications for the entire autosomal complement.—Using this method, we have succeeded in examining segmental aneuploids for 85% of chromosomes 2 and 3 in order to assess the effects of aneuploidy and to determine the number and location of dosage-sensitive loci in the Drosophila genome (Figure 5). Combining our data with previously reported results on the synthesis of Drosophila aneuploids (see Lindsley and Grell 1968), the following generalities emerge.—1. The X chromosome contains no triplo-lethal loci, few or no haplo-lethal loci, at least seven Minute loci, one hyperploid-sensitive locus, and one locus that is both triplo-abnormal and haplo-abnormal. 2. Chromosome 2 contains no triplo-lethal loci, few or no haplo-lethal loci, at least 17 Minute loci, and at least four other haplo-abnormal loci. 3. Chromosome 3 contains one triplo-lethal locus that is also haplo-lethal, few or no other haplo-lethal loci, at least 16 Minute loci, and at least six other haplo-abnormal loci. 4. Chromosome 4 contains no triplo-lethal loci, no haplo-lethal loci, one Minute locus, and no other haplo-abnormal loci.—Thus, the Drosophila genome contains 57 loci, aneuploidy for which leads to a recognizable effect on the organism: one of these is triplo-lethal and haplo-lethal, one is triplo-abnormal and haplo-abnormal, one is hyperploid-sensitive, ten are haplo-abnormal, 41 are Minutes, and three are either haplo-lethals or Minutes. Because of the paucity of aneuploid-lethal loci, it may be concluded that the deleterious effects of aneuploidy are mostly the consequence of the additive effects of genes that are slightly sensitive to abnormal dosage. Moreover, except for the single triplo-lethal locus, the effects of hyperploidy are much less pronounced than those of the corresponding hypoploidy.

This content is only available as a PDF.

© Genetics 1972

Citations

Views

Altmetric

Metrics

Total Views 331

0 Pageviews

331 PDF Downloads

Since 1/1/2021

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic