unc-93(e1500): A BEHAVIORAL MUTANT OF CAENORHABDITIS ELEGANS THAT DEFINES A GENE WITH A WILD-TYPE NULL PHENOTYPE (original) (raw)
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Department of Biology
, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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Department of Biology
, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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Published:
01 September 1980
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Iva S Greenwald, H Robert Horvitz, unc-93(e1500): A BEHAVIORAL MUTANT OF CAENORHABDITIS ELEGANS THAT DEFINES A GENE WITH A WILD-TYPE NULL PHENOTYPE, Genetics, Volume 96, Issue 1, 1 September 1980, Pages 147–164, https://doi.org/10.1093/genetics/96.1.147
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ABSTRACT
The uncoordinated, egg-laying-defective mutation, unc-93(e1500) III, of the nematode Caenorhabditis elegans spontaneously reverts to a wild-type phenotype. We describe 102 spontaneous and mutagen-induced revertants that define three loci, two extragenic (sup-9 II and sup-10 X) and one intragenic. Genetic analysis suggests that e1500 is a rare visible allele that generates a toxic product and that intragenic reversion, resulting from the generation of null alleles of the unc-93 gene, eliminates the toxic product. We propose that the genetic properties of the unc-93 locus, including the spontaneous reversion of the e1500 mutation, indicate that unc-93 may be a member of a multigene family. The extragenic suppressors also appear to arise as the result of elimination of gene activity; these genes may encode regulatory functions or products that interact with the unc-93 gene product. Genes such as unc-93, sup-9 and sup-10 may be useful for genetic manipulations, including the generation of deficiencies and mutagen testing.
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© Genetics 1980
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