Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China (original) (raw)

Journal Article

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1

Department of Epidemiology and Biostatistics

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Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University

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China

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3

Community Health Service Center

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Tianjin

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China

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Community Health Service Center

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Tianjin

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China

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Aging Research Center, Karolinska Institutet and Stockholm University

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Sweden

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Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University

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China

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Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University

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China

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Accepted:

24 September 2015

Published:

27 October 2015

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Fei Ma, Tianfeng Wu, Jiangang Zhao, Fengmei Han, Anna Marseglia, Huan Liu, Guowei Huang, Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China, The Journals of Gerontology: Series A, Volume 71, Issue 10, October 2016, Pages 1376–1383, https://doi.org/10.1093/gerona/glv183
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Abstract

Background:

This study is to examine the effects of folic acid supplementation on cognitive function in Chinese older adults with mild cognitive impairment who are unexposed to folic acid fortification and assess cognitive functioning in relation to folate, homocysteine, and vitamin B 12 values at baseline.

Methods:

This was a single-center, randomized, controlled trial in Tianjin, China; 180 individuals aged 65 years and older who had mild cognitive impairment were assigned randomly to one of two groups: (a) those treated with oral folic acid (400 µg/day) and (b) those treated via conventional treatment. Tests of cognitive performance and biomarkers were measured at baseline, 3 months, and 6 months. Analysis was by intention-to-treat. Changes in cognitive or clinical function were analyzed by repeated-measure analysis of variance or mixed-effects models. This trial has been registered with the trial number ChiCTR-TRC-13003227.

Results:

Total of 159 participants (intervention group: 80; control group: 79) completed the trial. Repeated-measure analysis of variance showed significant improvements in serum folate ( _ηp_2 = 0.712, p = .009), homocysteine ( _ηp_2 = 0.119, p = .017), serum vitamin B 12 ( _ηp_2 = 0.144, p = .022), and S -adenosylmethionine ( _ηp_2 = 0.117, p = .033) in the intervention group over the control group. Folic acid supplementation improved Full Scale IQ ( p = .031; effect size d = 0.168), Digit Span ( p = .009; d = 0.176), and Block Design ( p = .036; effect size d = 0.146) scores at 6 months in comparison to the control. There were no significant findings for all other cognitive measures.

Conclusion:

There was a beneficial effect from relatively short-term folate supplementation on cognitive functioning in later life. Larger-scale, randomized, controlled trials of longer duration in selected age groups are needed.

© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Topic:

• homocysteine
• folic acid
• biological markers
• china
• mental processes
• vitamin b12
• folic acid supplementation
• older adult
• minimal cognitive impairment
• cognitive ability
• intention to treat
• folic acid measurement, serum

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