A full Genome Scan for Late Onset Alzheimer's Disease (original) (raw)
Journal Article
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
,
Fabienne Wavrant-De Vrieze
1
Birdsall Building, Mayo Clinic
,
4500 San Pablo Road, Jacksonville, FL 32084, USA
Search for other works by this author on:
,
1
Birdsall Building, Mayo Clinic
,
4500 San Pablo Road, Jacksonville, FL 32084, USA
Search for other works by this author on:
,
2
Departments of Psychiatry and Genetics, Washington University School of Medicine
,
4940 Children's Place, St Louis, MO 63110, USA
Search for other works by this author on:
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
,
Neuropsychiatrie Genetics Unit, Tenovus Building, University of Wales College of Medicine
,
Heath Park Cardiff CF4 4XN
Search for other works by this author on:
Accepted:
20 November 1998
Published:
01 February 1999
Cite
Patrick Kehoe, Fabienne Wavrant-De Vrieze, Richard Crook, William S. Wu, Peter Holmans, Iain Fenton, Gillian Spurlock, Nadine Norton, Hywel Williams, Nigel Williams, Simon Lovestone, Jordi Perez-Tur, Mike Hutton, Marie-Christine Chartier-Harlin, Shantia Shears, Kimberly Roehl, Jeremy Booth, Wendy Van Voorst, Dzanan Ramic, Julie Williams, Alison Goate, John Hardy, Michael J. Owen, A full Genome Scan for Late Onset Alzheimer's Disease, Human Molecular Genetics, Volume 8, Issue 2, February 1999, Pages 237–245, https://doi.org/10.1093/hmg/8.2.237
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
We have genotyped 292 affected sibling pairs (ASPs) with Alzheimer's disease (AD) according to NINCDS-ADRDA diagnostic criteria and with onset ages of ≥65 years using 237 microsatellite markers separated by an average distance of 16.3 cM. Data were analysed by SPLINK and MAPMAKER/SIBS on the whole sample of 292 ASPs and subsets of 162 ASPs where both members possessed an apolipoprotein E (APOE) ε4 allele and 63 pairs where neither possessed an ε4 allele. Sixteen peaks with a multipoint lod score (MLS) >1 either in the whole sample, the ε4-positive or-negative subgroups were observed on chromosomes 1 (two peaks), 2, 5, 6, 9 (two peaks), 10 (two peaks), 12, 13, 14, 19, 21 and X (two peaks). Simulation studies revealed that these findings exceeded those expected by chance, although many are likely to be false positives. The highest lod scores on chromosomes 1 (MLS 2.67), 9 (MLS 2.38), 10 (MLS 2.27) and 19 (MLS 1.79) fulfil Lander and Kruglyak's definition of ‘suggestive’ in that they would be expected to occur by chance once or less per genome scan. Several other peaks were only marginally less significant than this, in particular those on chromosomes 14 (MLS 2.16), 5 (MLS 2.00), 12, close to α2-macroglobulin (MLS 1.91), and 21, close to amyloid precursor protein (MLS 1.77). This is the largest genome scan to date in AD and shows for the first time that this is a genetically complex disorder involving several, perhaps many, genes in addition to APOE. Moreover, our data will be of interest to those hoping to identify positional candidate genes using information emerging from neurobiological studies of AD.
© 1999 Oxford University Press
Topic:
- alleles
- alzheimer's disease
- lod score
- age of onset
- amyloid beta-protein precursor
- apolipoprotein e
- chromosomes
- genes
- genome
- macroglobulins
- microsatellite repeats
- alveolar soft part sarcoma
- relationship - sibling
- diagnosis
- advanced sleep phase syndrome
- false-positive results
- candidate disease gene
- alzheimer disease, late onset
- adult sensory processing scale
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
A full Genome Scan for Late Onset Alzheimer's Disease - 24 Hours access
EUR €38.00
GBP £33.00
USD $41.00
Rental
This article is also available for rental through DeepDyve.
Advertisement intended for healthcare professionals
Citations
Views
Altmetric
Metrics
Total Views 2,139
1,661 Pageviews
478 PDF Downloads
Since 1/1/2017
Month: | Total Views: |
---|---|
January 2017 | 2 |
February 2017 | 1 |
March 2017 | 15 |
April 2017 | 18 |
May 2017 | 7 |
June 2017 | 11 |
July 2017 | 11 |
August 2017 | 7 |
September 2017 | 8 |
October 2017 | 4 |
November 2017 | 4 |
December 2017 | 40 |
January 2018 | 19 |
February 2018 | 25 |
March 2018 | 29 |
April 2018 | 27 |
May 2018 | 29 |
June 2018 | 19 |
July 2018 | 15 |
August 2018 | 27 |
September 2018 | 18 |
October 2018 | 14 |
November 2018 | 30 |
December 2018 | 27 |
January 2019 | 14 |
February 2019 | 15 |
March 2019 | 21 |
April 2019 | 54 |
May 2019 | 78 |
June 2019 | 40 |
July 2019 | 29 |
August 2019 | 34 |
September 2019 | 53 |
October 2019 | 80 |
November 2019 | 57 |
December 2019 | 36 |
January 2020 | 43 |
February 2020 | 53 |
March 2020 | 17 |
April 2020 | 50 |
May 2020 | 9 |
June 2020 | 19 |
July 2020 | 9 |
August 2020 | 27 |
September 2020 | 25 |
October 2020 | 20 |
November 2020 | 17 |
December 2020 | 14 |
January 2021 | 26 |
February 2021 | 35 |
March 2021 | 30 |
April 2021 | 35 |
May 2021 | 28 |
June 2021 | 10 |
July 2021 | 21 |
August 2021 | 24 |
September 2021 | 22 |
October 2021 | 30 |
November 2021 | 23 |
December 2021 | 19 |
January 2022 | 28 |
February 2022 | 9 |
March 2022 | 27 |
April 2022 | 29 |
May 2022 | 14 |
June 2022 | 23 |
July 2022 | 19 |
August 2022 | 29 |
September 2022 | 36 |
October 2022 | 37 |
November 2022 | 26 |
December 2022 | 27 |
January 2023 | 24 |
February 2023 | 12 |
March 2023 | 28 |
April 2023 | 26 |
May 2023 | 17 |
June 2023 | 13 |
July 2023 | 24 |
August 2023 | 10 |
September 2023 | 14 |
October 2023 | 15 |
November 2023 | 8 |
December 2023 | 20 |
January 2024 | 15 |
February 2024 | 22 |
March 2024 | 10 |
April 2024 | 31 |
May 2024 | 18 |
June 2024 | 1 |
July 2024 | 1 |
October 2024 | 2 |
Citations
317 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic
Advertisement intended for healthcare professionals