Major genetic components underlying alcoholism in Korean population (original) (raw)

Journal Article

Dai-Jin Kim ,

1

Department of Psychiatry, Holy Family Hospital, College of Medicine

,

Catholic University of Korea

,

Sosa-dong, Wonmi-Gu, Pucheon, Kyounggi-do 420-717

,

Republic of Korea

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Ihn-Geun Choi ,

2

Department of Neuropsychiatry

,

Hallym University, Han-Gang Sacred Heart Hospital

,

94-200 Youngdungpo-Dong, Youngdungpo-Gu, Seoul 150-719

,

Republic of Korea

*To whom correspondence should be addressed. Tel: +82 220264288; Fax:

+82 220264299

; Email: [email protected]

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Byung Lae Park ,

3

Department of Genetic Epidemiology

,

SNP Genetics, Inc

.,

Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul 153-801

,

Republic of Korea

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Boung-Chul Lee ,

2

Department of Neuropsychiatry

,

Hallym University, Han-Gang Sacred Heart Hospital

,

94-200 Youngdungpo-Dong, Youngdungpo-Gu, Seoul 150-719

,

Republic of Korea

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Byung-Joo Ham ,

2

Department of Neuropsychiatry

,

Hallym University, Han-Gang Sacred Heart Hospital

,

94-200 Youngdungpo-Dong, Youngdungpo-Gu, Seoul 150-719

,

Republic of Korea

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Sujung Yoon ,

1

Department of Psychiatry, Holy Family Hospital, College of Medicine

,

Catholic University of Korea

,

Sosa-dong, Wonmi-Gu, Pucheon, Kyounggi-do 420-717

,

Republic of Korea

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Joon Seol Bae ,

3

Department of Genetic Epidemiology

,

SNP Genetics, Inc

.,

Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul 153-801

,

Republic of Korea

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Hyun Sub Cheong ,

3

Department of Genetic Epidemiology

,

SNP Genetics, Inc

.,

Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul 153-801

,

Republic of Korea

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Hyoung Doo Shin

3

Department of Genetic Epidemiology

,

SNP Genetics, Inc

.,

Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul 153-801

,

Republic of Korea

*To whom correspondence should be addressed. Tel: +82 220264288; Fax:

+82 220264299

; Email: [email protected]

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Received:

01 October 2007

Accepted:

30 November 2007

Published:

04 December 2007

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Dai-Jin Kim, Ihn-Geun Choi, Byung Lae Park, Boung-Chul Lee, Byung-Joo Ham, Sujung Yoon, Joon Seol Bae, Hyun Sub Cheong, Hyoung Doo Shin, Major genetic components underlying alcoholism in Korean population, Human Molecular Genetics, Volume 17, Issue 6, 15 March 2008, Pages 854–858, https://doi.org/10.1093/hmg/ddm357
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Abstract

Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. Alcohol dehydrogenase (ADH) converts alcohol to acetaldehyde, and aldehyde dehydrogenase (ALDH) converts acetaldehyde to acetate. The well-known genetic polymorphisms in ADH1B(His47Arg) and ALDH2(Glu487Lys) have dramatic effects on the rate of metabolizing alcohol and acetaldehyde, respectively. The protective allele of ADH1B (ADH1B*47His) encodes for a rapid ethanol-metabolizing enzyme, and the susceptible allele of the ALDH2 (ALDH2*487Lys) is strongly associated with decreased rate of metabolizing acetaldehyde. However, the combined genetic effects of both functional polymorphisms have not been clarified. The combined analysis of two polymorphisms among a Korean population (n = 1,032) revealed dramatic genetic effects on the risk of alcoholism. Individuals bearing susceptible alleles at both loci have 91 times greater risk for alcoholism [odds ratio (OR) = 91.43, P = 1.4 × 10−32] and individuals bearing one susceptible and one protective allele at either loci have 11 times greater risk (OR = 11.40, P = 3.5 × 10−15) compared with subjects who have both protective alleles. The attributable fraction of those genetic factors, calculated based on population controls, indicates that alcoholism in 86.5% of alcoholic patients can be attributed to the detrimental effect of ADH1B*47Arg and/or ALDH2*487Glu in Korean population.

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected]

Topic:

• alcohol dependence
• alleles
• ethanol
• acetaldehyde
• alcohol dehydrogenase
• aldehyde dehydrogenases
• polymorphism
• acetates
• genes
• population control
• enzymes
• genetics
• genetic aspects
• ethanol metabolism
• alcoholics

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