Evidence of Prevalent Genital-Type Human Papillomavirus Infections in Adults and Children (original) (raw)
Journal Article
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From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
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From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
Search for other works by this author on:
,
From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
Search for other works by this author on:
,
From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
Search for other works by this author on:
,
From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
Search for other works by this author on:
,
From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
Search for other works by this author on:
From the Fred Hutchinson Cancer Research Center, and the Departments of Medicine, Pathology, and Epidemiology, University of Washington
,
Seattle
Reprints and correspondence: Dr. Denise A. Galloway, Tumor Biology Office M616, Fred Hutchinson Cancer Research Center, 1124Columbia St., Seattle, WA98104.
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Received:
17 November 1989
Revision received:
05 February 1990
Cite
Steven A. Jenison, Xiu-ping Yu, Janette M. Valentine, Laura A. Koutsky, Audrey E. Christiansen, Anna Marie Beckmann, Denise A. Galloway, Evidence of Prevalent Genital-Type Human Papillomavirus Infections in Adults and Children, The Journal of Infectious Diseases, Volume 162, Issue 1, July 1990, Pages 60–69, https://doi.org/10.1093/infdis/162.1.60
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Abstract
Recombinant proteins encoded by the El, E7, Ll, and L2 open reading frames (ORF) of human papillomavirus (HPV) types 6b, 16, and 18were used in Western blot assays to detect serum IgO antibodies in women attending a sexually transmitted diseases clinic (n = 92) and in hospitalized children (n = 81). Antibodies to late gene products (Ll or L2 ORF) were more common than antibodies to early gene products (E2 or E7), both in the adults and the children; overall, the antibody prevalences in the children and the sexually active adults were not significantly different. Human sera with high titers of antibodies to the HPV16E7 recombinant protein immunoprecipitated the genuine HPV16 E7 protein from the cervical carcinoma cell line CaSki. As an independent measure of HPV infection, the polymerase chain reaction was used to detect HPV6b and HPV16 in oral mucosal scrapings from adults (n = 35) and preschool children (n = 21). In adults, HPV6b and HPV16 DNA were detected in 17% and 23% of oral mucosal samples, respectively. In preschool children, HPV6b and HPV16 DNA were found in 24% and 19% of oral samples, respectively.
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© 1990 by The University of Chicago
Topic:
- polymerase chain reaction
- western blotting
- recombinant proteins
- cervical cancer
- human papillomavirus
- adult
- cell lines
- child
- child, hospitalized
- preschool child
- dna
- genes
- oral mucous membrane
- open reading frames
- sexually transmitted diseases
- infections
- antibodies
- genital system
- cervix carcinoma
- serum
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