Spontaneous Production of Interleukin-6 by Alveolar Macrophages from Human Immunodeficiency Virus Type 1-Infected Patients (original) (raw)
Journal Article
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
,
Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
,
Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
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Padua University School of Medicine, Department of Clinical Medicine, 1st Medical Clinic and Clinical Immunology Branch, Institute of Histology and General Embryology; Departments ofPneumophysiology and Infectious Diseases, Padua Hospital
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Padua, Italy
Reprints or correspondence: Dr. Gianpietro Sernenzato, Istituto di Medicina Clinica dell'Università di Padova, Clinica Medica 1, Via Giustiniani 2, 35128 Padua, Italy
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Received:
15 November 1991
Revision received:
18 March 1992
Published:
01 October 1992
Cite
Livio Trentin, Spiridione Garbisa, Renato Zambello, Carlo Agostini, Cristina Caenazzo, Carla Di Francesco, Angiolo Cipriani, Ermenegildo Francavilla, Gianpietro Semenzato, Spontaneous Production of Interleukin-6 by Alveolar Macrophages from Human Immunodeficiency Virus Type 1-Infected Patients, The Journal of Infectious Diseases, Volume 166, Issue 4, October 1992, Pages 731–737, https://doi.org/10.1093/infdis/166.4.731
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Abstract
To test the hypothesis that the lung represents a source of interleukin (IL)-6 in human immunodeficiency virus type 1(HIV-1)-positive subjects,alveolar macrophages (AM)obtained from the bronchoalveolar lavage (HAL) fluid of 10 HIV-1-positive patients were investigated for the expression of IL-6 mRNA and the ability to release IL-6. The presence of IL-6 in BAL fluid was also investigated. It has been demonstrated that freshly recovered AM from HIV-1-positive patients showa strong IL-6 mRNA signal. The message for IL-6 increases following culture with LPS. Supernatants obtained from AM cultured in medium alone contain high amounts of IL-6; the values are three to four times higher following culture with LPS. IL-6 has also been detected in the BAL fluid from 5 of 8 HIV-I-positive patients. Results of immunoblotting analysis were consistent with those given above. These findings suggest that the lung represents a source of IL-6 production in HIV-1-infected subjects with lung disorders.
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© 1992 The University of Chicago
Topic:
- hiv
- lung
- lung diseases
- bronchial lavage
- hiv-1
- immunoblotting
- interleukins
- macrophages, alveolar
- rna, messenger
- interleukin-6
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