Cancer Risk After Iodine-131 Therapy for Hyperthyroidism (original) (raw)

Journal Article

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Department of Cancer Prevention, Rediumhemmet, Karolinska Hospital

Stockholm, Sweden

* Correspondence to: Lars-Erk Holm, M.D., Department of Cancer Prevention, Radiumhemmet, Karolinska Hospital, S-10401 Stockholm, Sweden

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Department of General Oncology, Rediumhemmet, Karolinska Hospital

Stockholm, Sweden

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Department of Cancer Epidemiology, Rediumhemmet, Karolinska Hospital

Stockholm, Sweden

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Department of General Oncology, Rediumhemmet, Karolinska Hospital

Stockholm, Sweden

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Department of General Oncology, Sahlgren's Hospital

Gothenburg, Sweden

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Department of General Oncology, Malmö General Hospital

Malmö, Sweden

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Department of General Oncology, University Hospital

Lund, Sweden

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Department of Internal Medicine, Malmö General Hospital

Malmö, Sweden

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Department of General Oncology, University Hospital

Ume´, Sweden

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Department of General Oncology, University Hospital

Ume´, Sweden

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Received:

14 November 1990

Revision received:

11 April 1991

Published:

07 August 1991

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Lars-Erik Holm, Per Hall, Kerstin Wiklund, Göran Lundell, Gertrud Berg, Göran Bjelkengren, Ebbe Cederquist, Ulla-Britt Ericsson, Arne Hallquist, Lars-Gunnar Larsson, Monika Lidberg, Sture Lindberg, Jan Tennvall, Harriet Wicklund, John D. Boice, Cancer Risk After Iodine-131 Therapy for Hyperthyroidism, JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Pages 1072–1077, https://doi.org/10.1093/jnci/83.15.1072
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Abstract

Cancer incidence was studied in 10 552 patients (mean age, 57 years) who received 131 I therapy (mean dose, 506 MBq) for hyperthyroidism between 1950 and 1975. Follow-up on these patients was continued for an average of 15 years. Record linkage with the Swedish Cancer Register for the period 1958–1985 identified 1543 cancers occurring 1 year or more after 131 I treatment, and the standardized incidence ratio (SIR) was 1.06 (95% confidence interval = 1.01–1.11). Significantly increased SIRs were observed for cancers of the lung (SIR = 1.32; n = 105) and kidney (SIR = 1.39; n = 66). Among 10-year survivors, significantly elevated risks were seen for cancers of the stomach (SIR = 1.33; n = 58), kidney (SIR = 1.51; n = 37), and brain (SIR = 1.63; n = 30). Only the risk for stomach cancer, however, increased over time (P<.05) and with increasing activity administered (P = not significant). The risk for malignant lymphoma was significantly below expectation (SIR = 0.53; n = 11). Overall cancer risk did not increase with administered 131 I dose or with time since exposure. The absence of any increase in leukemia adds further support to the view that a radiation dose delivered gradually over time is less carcinogenic than the same total dose received over a short time. Only for stomach cancer was a possible radiogenic excess suggested. [J Natl Cancer Inst 83: 1072–1077, 1991]

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Topic:

• hyperthyroidism
• systemic inflammatory response syndrome
• cancer
• gastric cancer
• follow-up
• leukemia
• lymphoma
• radiotherapy dosage
• survivors
• brain
• kidney
• lung cancer
• iodine-131
• cancer risk

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