Chronic Stress and Susceptibility to Skin Cancer (original) (raw)

Journal Article

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Correspondence to: Firdaus S. Dhabhar, PhD, 4179 Postle Hall, 305 W. 12th Ave., Columbus, OH 43210 (e-mail: dhabhar@rockefeller.edu ).

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

,

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

Affiliations of authors: Colleges of Medicine and Public Health (ANS, TMO, S. Jones, S. Jewell, WBM, SL, FSD), Dentistry (CD, FSD), and Veterinary Medicine (DK), Institute of Behavioral Medicine Research (WBM, SL, FSD), Center for Biostatistics (AL, SL), The Ohio State University, Columbus, OH

Search for other works by this author on:

Revision received:

17 August 2005

Accepted:

14 October 2005

Published:

07 December 2005

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Alison N. Saul, Tatiana M. Oberyszyn, Christine Daugherty, Donna Kusewitt, Susie Jones, Scott Jewell, William B. Malarkey, Amy Lehman, Stanley Lemeshow, Firdaus S. Dhabhar, Chronic Stress and Susceptibility to Skin Cancer, JNCI: Journal of the National Cancer Institute, Volume 97, Issue 23, 7 December 2005, Pages 1760–1767, https://doi.org/10.1093/jnci/dji401
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Background: Studies have shown that chronic stress or UV radiation independently suppress immunity. Given their increasing prevalence, it is important to understand whether and how chronic stress and UV radiation may act together to increase susceptibility to disease. Therefore, we investigated potential mediators of a stress-induced increase in emergence and progression of UV-induced squamous cell carcinoma. Methods: SKH1 mice susceptible to UV-induced tumors were unexposed (naïve, n = 4) or exposed ( n = 16) to 2240 J/m 2 of UVB radiation three times a week for 10 weeks. Half of the UVB-exposed mice were left nonstressed (i.e., they remained in their home cages) and the other half were chronically stressed (i.e., restrained during weeks 4–6). UV-induced tumors were measured weekly from week 11 through week 34, blood was collected at week 34, and tissues were collected at week 35. mRNA expression of interleukin (IL)-12p40, interferon (IFN)-γ, IL-4, IL-10, CD3ϵ, and CCL27/CTACK, the skin T cell–homing chemokine, in dorsal skin was quantified using real-time polymerase chain reaction. CD4 + , CD8 + , and CD25 + leukocytes were counted using immunohistochemistry and flow cytometry. All statistical tests were two-sided. Results: Stressed mice had a shorter median time to first tumor (15 versus 16.5 weeks, difference = 1.5 weeks, 95% confidence interval [CI] = −3.0 to 3.3 weeks; P = .03) and reached 50% incidence earlier than controls (15 weeks versus 21 weeks). Stressed mice also had lower IFN-γ ( mean = 0.03 versus mean = 0.07, difference = 0.04, 95% CI = 0.004 to 0.073; P = .02), CCL27/CTACK (mean = 101 versus mean = 142, difference = 41, 95% CI = 8.1 to 74.4; P = .03), and CD3ϵ (mean = 0.18 versus mean = 0.36, difference = 0.18, 95% CI = 0.06 to 0.30; P = .007) gene expression and lower numbers of infiltrating CD4 + cells (mean = 9.40 versus mean = 13.7, difference = 4.3, 95% CI = 2.36 to 6.32; P = .008) than nonstressed mice. In addition, stressed mice had more regulatory/suppressor CD25 + cells infiltrating tumors and more CD4 + CD25 + cells in circulation (mean = 0.36 versus mean = 0.17, difference = 0.19, 95% CI = 0.005 to 0.38; P = .03) than nonstressed mice. Conclusions: Chronic stress increased susceptibility to UV-induced squamous cell carcinoma in this mouse model by suppressing type 1 cytokines and protective T cells and increasing regulatory/suppressor T cell numbers.

© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org.

Topic:

• gene expression
• squamous cell carcinoma
• t-lymphocytes
• mice
• neoplasms
• stress
• skin cancer
• ultraviolet b radiation

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Chronic Stress and Susceptibility to Skin Cancer - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 4,023

3,103 Pageviews

920 PDF Downloads

Since 12/1/2016

Citations

150 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic