Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality (original) (raw)
Journal Article
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Lin Shen ,
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Affiliations of authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China (WCY, JLM, LZ, JYL, LS, KFP); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD (JFF, MHG); Linqu County Public Health Bureau, Shandong, China (WDL, ZXH); Westat, Rockville, MD (YH, SCM); Information Management Services, Rockville, MD (DP); RTI International, Rockville, MD, (LMB); International Epidemiology Institute, Ltd, Rockville, MD (WJB); Vanderbilt University Medical Center, Nashville, TN (WJB)
Search for other works by this author on:
Revision received:
13 December 2011
Accepted:
28 December 2011
Published:
23 January 2012
Cite
Jun-Ling Ma, Lian Zhang, Linda M. Brown, Ji-You Li, Lin Shen, Kai-Feng Pan, Wei-Dong Liu, Yuanreng Hu, Zhong-Xiang Han, Susan Crystal-Mansour, David Pee, William J. Blot, Joseph F. Fraumeni, Wei-Cheng You, Mitchell H. Gail, Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality, JNCI: Journal of the National Cancer Institute, Volume 104, Issue 6, 21 March 2012, Pages 488–492, https://doi.org/10.1093/jnci/djs003
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
In the Shandong Intervention Trial, 2 weeks of antibiotic treatment for Helicobacter pylori reduced the prevalence of precancerous gastric lesions, whereas 7.3 years of oral supplementation with garlic extract and oil (garlic treatment) or vitamin C, vitamin E, and selenium (vitamin treatment) did not. Here we report 14.7-year follow-up for gastric cancer incidence and cause-specific mortality among 3365 randomly assigned subjects in this masked factorial placebo-controlled trial. Conditional logistic regression was used to estimate the odds of gastric cancer incidence, and the Cox proportional hazards model was used to estimate the relative hazard of cause-specific mortality. All statistical tests were two-sided. Gastric cancer was diagnosed in 3.0% of subjects who received H pylori treatment and in 4.6% of those who received placebo (odds ratio = 0.61, 95% confidence interval = 0.38 to 0.96, P = .032). Gastric cancer deaths occurred among 1.5% of subjects assigned H pylori treatment and among 2.1% of those assigned placebo (hazard ratio [HR] of death = 0.67, 95% CI = 0.36 to 1.28). Garlic and vitamin treatments were associated with non-statistically significant reductions in gastric cancer incidence and mortality. Vitamin treatment was associated with statistically significantly fewer deaths from gastric or esophageal cancer, a secondary endpoint (HR = 0.51, 95% CI = 0.30 to 0.87; P = .014).
Published by Oxford University Press 2012.
Topic:
- antibiotics
- vitamin e
- selenium
- esophageal cancer
- gastric cancer
- helicobacter pylori
- follow-up
- vitamins
- ascorbic acid
- garlic
- mortality
- gastric lesions
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality - 24 Hours access
EUR €39.00
GBP £33.00
USD $43.00
Rental
This article is also available for rental through DeepDyve.