Where Does Parkinson Disease Pathology Begin in the Brain? (original) (raw)

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Departments of Clinical Neuroanatomy (HB, KDT, UR), J.W. Goethe University, Frankfurt am Main, Germany; Department of Pathology (JREB), Johannes Gutenberg University, Mainz, Germany; Laboratorium Pathologie Oost Nederland (RAIdV), Enschede, The Netherlands

Correspondence to: Dr. Kelly Del Tredici, Department of Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany

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Departments of Clinical Neuroanatomy (HB, KDT, UR), J.W. Goethe University, Frankfurt am Main, Germany; Department of Pathology (JREB), Johannes Gutenberg University, Mainz, Germany; Laboratorium Pathologie Oost Nederland (RAIdV), Enschede, The Netherlands

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Departments of Clinical Neuroanatomy (HB, KDT, UR), J.W. Goethe University, Frankfurt am Main, Germany; Department of Pathology (JREB), Johannes Gutenberg University, Mainz, Germany; Laboratorium Pathologie Oost Nederland (RAIdV), Enschede, The Netherlands

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Departments of Clinical Neuroanatomy (HB, KDT, UR), J.W. Goethe University, Frankfurt am Main, Germany; Department of Pathology (JREB), Johannes Gutenberg University, Mainz, Germany; Laboratorium Pathologie Oost Nederland (RAIdV), Enschede, The Netherlands

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Departments of Clinical Neuroanatomy (HB, KDT, UR), J.W. Goethe University, Frankfurt am Main, Germany; Department of Pathology (JREB), Johannes Gutenberg University, Mainz, Germany; Laboratorium Pathologie Oost Nederland (RAIdV), Enschede, The Netherlands

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Received:

30 October 2001

Revision received:

11 February 2002

Accepted:

12 February 2002

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Kelly Del Tredici, Udo Rüb, Rob A.I. de Vos, Jürgen R.E. Bohl, Heiko Braak, Where Does Parkinson Disease Pathology Begin in the Brain?, Journal of Neuropathology & Experimental Neurology, Volume 61, Issue 5, May 2002, Pages 413–426, https://doi.org/10.1093/jnen/61.5.413
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Abstract

The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immunoreactive Lewy neurites and Lewy bodies in non-catecholaminergic neurons of the dorsal glossopharyngeus-vagus complex, in projection neurons of the intermediate reticular zone, and in specific nerve cell types of the gain setting system (coeruleus-subcoeruleus complex, caudal raphe nuclei, gigantocellular reticular nucleus), olfactory bulb, olfactory tract, and/or anterior olfactory nucleus in the absence of nigral involvement. The topographical parcellation of the nuclear grays described here is based upon known architectonic analyses of the human brainstem and takes into consideration the pigmentation properties of a few highly susceptible nerve cell types involved in PD. In this sample and in all 58 age- and gender-matched controls, Lewy bodies and Lewy neurites do not occur in any of the known prosencephalic predilection sites (i.e. hippocampal formation, temporal mesocortex, proneocortical cingulate areas, amygdala, basal nucleus of Meynert, interstitial nucleus of the diagonal band of Broca, hypothalamic tuberomamillary nucleus).

Copyright © 2002 by the American Association of Neuropathologists

Topic:

• parkinson disease
• amygdala
• autopsy
• cell nucleus
• diagonal band of broca
• lesch-nyhan syndrome
• lewy bodies
• neurites
• neurons
• olfactory bulb
• pigmentation
• raphe nuclei
• smell perception
• substantia nigra
• vagus nerve
• basal nucleus of meynert
• brain
• brain stem
• pathology
• gender
• thalamic reticular nucleus
• olfactory tract
• mesocortex
• hippocampal formation
• projection neuron

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