Retrovirus-related sequences in human DNA: detection and cloning of sequences which hybridize with the long terminal repeat of baboon endogenous virus (original) (raw)

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,

Department of Microbiology, Keio University School of Medicine

Tokyo, Japan

* Present address of M. N.: Laboratory of Tumor virus Genetics, National Cancer Institute, Bethesda, Maryland 20205, U.S.A.

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Department of Microbiology, Keio University School of Medicine

Tokyo, Japan

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Department of Microbiology, Keio University School of Medicine

Tokyo, Japan

• All the inquiries should be addressed to T. T.

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* Present address of M. N.: Laboratory of Tumor virus Genetics, National Cancer Institute, Bethesda, Maryland 20205, U.S.A.

Author Notes

Received:

15 February 1982

Revision received:

23 April 1982

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Makoto Noda, Masano Kurihara, Toshiya Takano, Retrovirus-related sequences in human DNA: detection and cloning of sequences which hybridize with the long terminal repeat of baboon endogenous virus, Nucleic Acids Research, Volume 10, Issue 9, 11 May 1982, Pages 2865–2878, https://doi.org/10.1093/nar/10.9.2865
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Abstract

Human DNA sequences which hybridized with the long terminal repeats (LTR) of baboon type C virus M7 were detected by non-stringent blot hybridization. About 7 to 10 discrete bands of the LTS-related sequences were commonly observed in the DNAs from four independent human cell lines after digestion with either Eco RI, Hind III or Bam HI. The amounts of these sequences were more abundant in tumor cell lines than in a non-malignant cell line. The human sequences related to the M7 LTR seemed to be located at relatively specific sites on the cell DNA. The human DNA clones which hybridized with M7 LTR were detected in the human DNA library described by Lawn etal . (Cell 15, 1157–1174, 1978), at a frequency of about 300 per haploid genome. Five clones were isolated which shared different extent of homology with M7 LTR and whose restriction maps were totally different one another. The DNA structures of two of them resembled the genome of retroviruses. These results suggest the presence of various types of the LTR-related sequences in human DNA: some of them might represent endogenous virus genomes of human cells.

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Author notes

* Present address of M. N.: Laboratory of Tumor virus Genetics, National Cancer Institute, Bethesda, Maryland 20205, U.S.A.

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