Non-Alu family interspersed repeats in human DNA and their transcriptional activity (original) (raw)

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1

Biochemistry and Biophysics, University of California

Davis, CA 95616

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* To whom correspondence should be communicated

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Department of Microbiology and Immunology, Albert Einstein College of Medicine

Bronx, NY 10461, USA

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Department of Microbiology and Immunology, Albert Einstein College of Medicine

Bronx, NY 10461, USA

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Received:

18 January 1984

Accepted:

29 February 1984

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Lily Sun, K.Eric Paulson, Carl W. Schmid, Lisa Kadyk, Leslie Leinwand, Non-Alu family interspersed repeats in human DNA and their transcriptional activity, Nucleic Acids Research, Volume 12, Issue 6, 26 March 1984, Pages 2669–2690, https://doi.org/10.1093/nar/12.6.2669
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Abstract

Randomly selected human genomic clones have been surveyed for the presence of non-Alu family interspersed repeats. Four such families of repeats have been isolated and characterized with respect to repetition frequency, interspersion, base sequence, sequence divergence, in vitro RNA polymerase III transcription, elongation of transcripts in isolated nuclei, and in vivo transcription. The two most abundant of the four families of repeats correspond to previously reported families of repeats, namely the Kpn I family and poly (CA). We conclude that most of the highly repetitive (> 50,000 copies) human interspersed repeats have already been identified. Two lower abundance repeats families are also described here

The abundance with which each of these families is represented in nuclear RNA qualitatively corresponds to their genomic reiteration frequencies. Further, the complementary strands of each repeat family are approximately symmetrically transcribed. The abundance of these repeats in cytoplasmic RNA is qualitatively less than in nuclear RNA. The bulk of the in vivo transcriptional activity of these repeats thus appears to be nonspecific read through from other promoters

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© 1984 IRL Press Ltd.

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