Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization (original) (raw)
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Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio
7703 Floyd Curl Drive, San Antonio, TX 78284, USA
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Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio
7703 Floyd Curl Drive, San Antonio, TX 78284, USA
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*Molecular Therapeutics, Inc., 400 Morgan Lane, West Haven, Connecticut 06516.
Revision received:
10 August 1985
Published:
11 September 1985
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Glenn E. Nedwin, Susan L. Naylor, Alan Y. Sakaguchi, Douglas Smith, Julie Jarrett-Nedwin, Diane Pennica, David V. Goeddel, Patrick W. Gray, Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization, Nucleic Acids Research, Volume 13, Issue 17, 11 September 1985, Pages 6361–6373, https://doi.org/10.1093/nar/13.17.6361
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Abstract
Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).
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*Molecular Therapeutics, Inc., 400 Morgan Lane, West Haven, Connecticut 06516.
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