The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-α-trypsin inhibitor also encodes α-1-microgiobulin (protein HC (original) (raw)
Journal Article
Recombinant DNA-Chemistry, Microbiology Research, Biotechnology Group
PO Box 932, Miles Laboratories, Inc., Elkhart, IN 46515, USA
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Recombinant DNA-Chemistry, Microbiology Research, Biotechnology Group
PO Box 932, Miles Laboratories, Inc., Elkhart, IN 46515, USA
Search for other works by this author on:
Recombinant DNA-Chemistry, Microbiology Research, Biotechnology Group
PO Box 932, Miles Laboratories, Inc., Elkhart, IN 46515, USA
Search for other works by this author on:
Accepted:
15 September 1986
Published:
01 October 1986
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John F. Kaumeyer, Joseph O. Polazzi, Michael P. Kotick, The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-α-trypsin inhibitor also encodes α-1-microgiobulin (protein HC, Nucleic Acids Research, Volume 14, Issue 20, 1 October 1986, Pages 7839–7850, https://doi.org/10.1093/nar/14.20.7839
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Abstract
Inter-a-trypsin inhibitor (ITI) is a 180 kd serine proteinase inhibitor found in human serum. Treatment of 180 kd ITI with trypsin releases a 30 kd fragment (HI-30) which contains the anti-proteolytic activity of the high molecular weight form. We have isolated a cDNA clone from a human liver library which codes for HI-30, and have determined its DNA sequence. The mRNA not only codes for HI-30 but also another serum protein, α1-microglobulin, which has not been previously associated with ITI or HI-30. The α-1-microglobulin sequence is found in the amino-terminus of the protein and is preceded by a signal sequence. HI-30 is found at the carboxy-terminus. The two protein sequences are separated by two arginine residues.
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