Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1 (original) (raw)
Journal Article
,
Institute of Virology, Church Street
Glasgow Gll 5JR, UK
2 Members of the MRC Virology Unit
1 To whom correspondence should be addressed
Search for other works by this author on:
,
Institute of Virology, Church Street
Glasgow Gll 5JR, UK
2 Members of the MRC Virology Unit
Search for other works by this author on:
,
Institute of Virology, Church Street
Glasgow Gll 5JR, UK
2 Members of the MRC Virology Unit
Search for other works by this author on:
Institute of Virology, Church Street
Glasgow Gll 5JR, UK
3 Present address: Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Search for other works by this author on:
2 Members of the MRC Virology Unit
3 Present address: Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Received:
10 January 1986
Accepted:
04 February 1986
Published:
25 February 1986
Cite
Duncan J. McGeoch, Aidan Dolan, Sally Donald, Dieter H.K. Brauer, Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1, Nucleic Acids Research, Volume 14, Issue 4, 25 February 1986, Pages 1727–1745, https://doi.org/10.1093/nar/14.4.1727
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
We report the complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1, as 6633 base pairs of composition 79.5% G+C. This contains immediate early gene 3, encoding the IE175 protein, an important transcriptional activator of later virus genes. The IE175 coding region was identified as a 3894 base sequence of 81.5% G+C DNA. The base composition of this gene is thus the most extreme yet determined, and the IE175 predicted amino acid composition is correspondingly biased, most notably with an alanine content of 20.9%. Functionally important regions of the IE175 polypeptide were tentatively identified by comparison with the sequence of the homologous protein from varicella-zoster virus and from locations of ts mutations, and were correlated with properties of the amino acid sequence. Aspects of the evolution of such an extreme composition DNA sequence were discussed.
This content is only available as a PDF.
Author notes
2 Members of the MRC Virology Unit
3 Present address: Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
© IRL Press Limited
I agree to the terms and conditions. You must accept the terms and conditions.
Submit a comment
Name
Affiliations
Comment title
Comment
You have entered an invalid code
Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.
Citations
Views
Altmetric
Metrics
Total Views 250
40 Pageviews
210 PDF Downloads
Since 2/1/2017
Month: | Total Views: |
---|---|
February 2017 | 6 |
July 2017 | 1 |
August 2017 | 2 |
September 2017 | 5 |
October 2017 | 4 |
December 2017 | 68 |
January 2018 | 56 |
February 2018 | 7 |
March 2018 | 19 |
April 2018 | 12 |
August 2018 | 1 |
May 2019 | 1 |
July 2019 | 3 |
March 2020 | 1 |
April 2020 | 2 |
June 2020 | 1 |
August 2020 | 1 |
January 2021 | 2 |
March 2021 | 2 |
April 2021 | 1 |
June 2021 | 1 |
December 2021 | 1 |
March 2022 | 3 |
April 2022 | 1 |
August 2022 | 3 |
September 2022 | 1 |
October 2022 | 1 |
November 2022 | 9 |
March 2023 | 1 |
August 2023 | 1 |
September 2023 | 1 |
January 2024 | 1 |
April 2024 | 3 |
May 2024 | 5 |
June 2024 | 6 |
July 2024 | 4 |
August 2024 | 5 |
September 2024 | 3 |
October 2024 | 5 |
Citations
311 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic