A ‘hot-spot’ for Ty transposition on the left arm of yeast chromosome III (original) (raw)
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Department of Microbiology UMDNJ - New Jersey Medical School
100 Bergen Street, Newark, NJ 07103, USA
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*To whom correspondence should be addressed
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2Present address: Department of Parmacology, UMDNJ, Rutgers Medical School Piscataway, NJ 08854, USA
3Present address: Allelix Inc., 6850 Goreway Drive, Mississauga, Ontario L4V IPI, Canada
Received:
12 February 1986
Revision received:
27 March 1986
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John R. Warmington, Rashida Anwar, Carol S. Newlon, Richard B. Waring, R. Wayne Davies, Keith J. Indge, Stephen G. Oliver, A ‘hot-spot’ for Ty transposition on the left arm of yeast chromosome III, Nucleic Acids Research, Volume 14, Issue 8, 11 April 1986, Pages 3475–3485, https://doi.org/10.1093/nar/14.8.3475
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Abstract
The small ring derivative of Saccharomyces cerevisiae chromosome III, which was formed by a cross-over between HML on the left arm and HMR on the right arm, contains three Ty elements. The class II element Ty 1-17 lies immediately centromere-distal to LEU2 on the left arm while two class I elements are tandemly arranged distal to PGK on the right arm. We have sequenced the regions of chromosome III surrounding Ty 1-17 and have defined a region where a number of transposition events have occurred. This region is flanked by the 5' ends of two tRNA genes, tRNA3Glu on the centromere distal side and tRNA3Leu immediately in front of LEU2. Close to the tRNA3Glu gene there is a region containing degenerate delta sequences organised in opposite orientations. Immediately distal to Ty 1-17 there are two complete solo delta elements, one inserted into the other. The sequence indicates that these two delta sequences were inserted into chromosome III by separate transposition events. A model is presented to explain how this structure arose and the role of solo delta elements in transposon propagation and maintenance is discussed.
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Author notes
2Present address: Department of Parmacology, UMDNJ, Rutgers Medical School Piscataway, NJ 08854, USA
3Present address: Allelix Inc., 6850 Goreway Drive, Mississauga, Ontario L4V IPI, Canada
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