The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus (original) (raw)
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1
Program Resources Inc., Frederick Cancer Research Facility
Frederick, MD 21701
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Laboratory of Cell Biology, National Institute of Mental Health
Bethesda, MD 20205, USA
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Received:
09 September 1986
Revision received:
05 December 1986
Accepted:
05 December 1986
Published:
26 January 1987
PDF Cite
T.W. Beck, M. Huleihel, M. Gunnell, T.I. Bonner, U.R. Rapp, The complete coding sequence of the human A-_raf_-1 oncogene and transforming activity of a human A-raf carrying retrovirus, Nucleic Acids Research, Volume 15, Issue 2, 26 January 1987, Pages 595–609, https://doi.org/10.1093/nar/15.2.595
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Abstract
The complete 606 amino acid sequence of the human A-raf oncogene has been deduced from the 2453 nucleotide sequence of a human T cell cDNA. A cysteine-rich region located near the amino terminus, which is highly conserved in A-raf and c-raf. shows significant homology with protein kinase C. A 5′ deleted fragment of the cDNA has been incorporated into a murine retrovirus which endows the virus with the ability to transform cells in vivo and in vitro. Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function.
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