The human HOX gene family (original) (raw)

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International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

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International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

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,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

,

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

Search for other works by this author on:

International Institute of Genetics and Biophysics

CNR, Via Marconi 10, 80125 Naples, Italy

* To whom correspondence should be addressed

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Received:

27 September 1989

Revision received:

16 November 1989

Accepted:

16 November 1989

Published:

25 December 1989

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Dario Acampora, Maurizio D'Esposito, Antonio Faiella, Maria Pannese, Enrica Migliaccio, Franco Morelli, Anna Stornaiuolo, Vincenzo Nigro, Antonio Simeone, Edoardo Boncinelli, The human HOX gene family, Nucleic Acids Research, Volume 17, Issue 24, 25 December 1989, Pages 10385–10402, https://doi.org/10.1093/nar/17.24.10385
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Abstract

We report the identification of 10 new human homeobox sequences. Altogether, we have isolated and sequenced 30 human Hhomeoboxes clustered in 4 chromosomal regions called HOX loci. HOX1 includes 8 homeoboxes in 90 kb of DNA on chromosome 7. HOX2 includes 9 homeoboxes in 180 kb on chromosome 17. HOX3 contains at least 7 homeoboxes in 160 kb on chromosome 12. Finally, HOX4 includes 6 homeoboxes in 70 kb on chromosome 2. Homeodomains obtained from the conceptual translation of the isolated homeoboxes can be attributed to 13 homology groups on the basis of their primary peptide sequence. Moreover, it is possible to align the 4 HOX loci so that corresponding homeodomains in all loci share the maximal sequence identity. The complex of these observations supports and extends an evolutionary hypothesis concerning the origin of mammalian and fly homeobox gene complexes. We also determined the coding region present in 3 HOX2 cDNA clones corresponding to HOX2G, HOX2H and HOX21.

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