Detection of a specific mitochondrial DNA deletion in tissues of older humans (original) (raw)
Journal Article
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Molecular Biology Section, University of Southern California
Los Angeles, CA 90089-1340, USA
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Molecular Biology Section, University of Southern California
Los Angeles, CA 90089-1340, USA
Search for other works by this author on:
Published:
01 January 1990
Revision received:
25 October 1990
Accepted:
25 October 1990
PDF Cite
Gino A. Cortopassi, Norman Arnheim, Detection of a specific mitochondrial DNA deletion in tissues of older humans, Nucleic Acids Research, Volume 18, Issue 23, 1 December 1990, Pages 6927–6933, https://doi.org/10.1093/nar/18.23.6927
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Abstract
Using PCR, we found that normal heart muscle and brain from adult human individuals contain low levels of a specific mitochondrial DNA deletion, previously found only in patients affected with certain types of neuromuscular disease. This deletion was not observed in fetal heart or brain. Experimental tests support the idea that the deletion exists in vivo in adult mitochondria and Is not an in vitro artifact of PCR. Our data provide direct experimental support for the idea that accumulation of mitochondrial DNA deletions may be Important in aging.
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