Three new members of the RNP protein family in Xenopus (original) (raw)

Journal Article

,

Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health

Bethesda, MD 20892, USA

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Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health

Bethesda, MD 20892, USA

Search for other works by this author on:

Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health

Bethesda, MD 20892, USA

Search for other works by this author on:

Received:

28 September 1992

Revision received:

07 January 1993

Accepted:

07 January 1993

Published:

25 February 1993

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Peter J. Good, Martha L. Rebbert, lgor B. Dawid, Three new members of the RNP protein family in Xenopus, Nucleic Acids Research, Volume 21, Issue 4, 25 February 1993, Pages 999–1006, https://doi.org/10.1093/nar/21.4.999
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Abstract

Many RNP proteins contain one or more copies of the RNA recognition motif (RRM) and are thought to be involved in cellular RNA metabolism. We have previously characterized in Xenopus a nervous system specific gene, _nrp_1, that is more simliar to the hnRNP A/B proteins than to other known proteins (K.Richter, P.J.Good, and I.B.Dawid (1990), New Blol. 2,556-565). PCR amplification with degenerate primers was used to identify additional cDNAs encoding two RRMs in Xenopus. Three previously uncharacterlzed genes were identified. Two genes encode hnRNP A/B proteins with two RRMs and a glycine-rich domain. One of these is the Xenopus homoiog of the human A2/B1 gene; the other, named hnRNP A3, is similar to both the A1 and A2 hnRNP genes. The Xenopus hnRNP A1, A2 and A3 genes are expressed throughout development and in all adult tissues. Multiple protein isoforms for the hnRNP A2 gene are predicted that differ by the insertion of short peptide sequences in the glycine-rich domain. The third newly isolated gene, named xrp1, encodes a protein that is related by sequence to the nrpl protein but is expressed ubiquitously. Despite the similarity to nuclear RNP proteins, both the nrp1 and xrp1 proteins are localized to the cytoplasm in the Xenopus oocyte. The xrp1 gene may have a function in all cells that is similar to that executed by nrp1 specifically within the nervous system.

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© 1993 Oxford University Press

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