Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120 (original) (raw)

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Eugene V. Koonin, Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120, Nucleic Acids Research, Volume 22, Issue 13, 11 July 1994, Pages 2476–2478, https://doi.org/10.1093/nar/22.13.2476
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Abstract

Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferationassociated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.

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