A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6–4 photoproducts (original) (raw)
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Center for Radiological Research, Columbia University College of Physicians and Surgeons
630 W. 168 Street, New York, NY 10032
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department of Chemistry, Washington University
St Louis, MO 63130, USA
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department of Chemistry, Washington University
St Louis, MO 63130, USA
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Center for Radiological Research, Columbia University College of Physicians and Surgeons
630 W. 168 Street, New York, NY 10032
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Revision received:
06 July 1994
Published:
11 August 1994
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Krista K. Bowman, Khalifah Sidik, Colin A. Smith, John-Stephen Taylor, Paul W. Doetsch, Greg A. Freyer, A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6–4 photoproducts, Nucleic Acids Research, Volume 22, Issue 15, 11 August 1994, Pages 3026–3032, https://doi.org/10.1093/nar/22.15.3026
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Abstract
We have discovered a new DNA endonuclease in the fission yeast Schizosaccharomyces pombe which recognizes cyclobutane pyrimidine dimers and (6–4) pyrimidine-pyrimidone photoproducts. S.pombe DNA endonuclease (SPDE) catalyzes a single ATPindependent incision immediately 5′ to the UV photoproduct and generates termini containing 3′ hydroxyl and 5′ phosphoryl groups. Based on these properties, we propose that SPDE may function in a DNA repair capacity, representing the initial recognition/ cleavage step of a DNA excision repair pathway.
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