The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1 (original) (raw)

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Gene Expression Programme, EMBL

Meyerhofstraβe 1, D-69117 Heidelberg, Germany

* To whom correspondence should be addressed at present address: Laboratory of Biotechnology, University of Bergen, HiB, Thormohlensgt. 55, N-5020 Bergen, Norway

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Gene Expression Programme, EMBL

Meyerhofstraβe 1, D-69117 Heidelberg, Germany

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Published:

25 August 1995

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Rein Assland, Francls stewart, The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1, Nucleic Acids Research, Volume 23, Issue 16, 25 August 1995, Pages 3168–3173, https://doi.org/10.1093/nar/23.16.3168
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Abstract

The chromo domain was originally Identified as a protein sequence motif common to the Drosophlla chromatin proteins, Polycomb (Pc) and Heterochromatin protein 1 [HP1; Paro and Hogness (1991) Proc. Natl. Acad. Scl . USA, 88, 263–267; Paro (1990) Trends Genet, 6, 416–421]. Here we describe a second chromo domain-like motif in HP1. Subsequent refined searches Identified further examples of this chromo domain variant which all occur in proteins that also have an N-terminally located chromo domain. Due to its relatedness to the chromo domain, and Its occurrence In proteins that also have a classical chromo domain, we call the variant the ‘chromo shadow domain’. Chromo domain-containing proteins can therefore be divided Into two classes depending on the presence, for example in HP1, or absence, for example in Pc, of the chromo shadow domain. We have also found examples of proteins which have two classical chromo domains. The Schizosaccharomyces pombe SWI6 protein, involved In repression of the silent mating-type loci, is a member of the chromo shadow group. The similar modular architecture of SpSWI6, HP1 and HP1-like proteins supports the model that the specificity of action of chromatin proteins is generated by combinations of protein modules.

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