Base pairing structure in the poly d(G-T) double helix: wobble base pairs (original) (raw)

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Max-Planck-Institut für Experimentelle Medizin

Abt. Chemie, Göttingen, GFR

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Thomas A. Early, John Olmsted, David R. Kearns, Axel G. Lezius, Base pairing structure in the poly d(G-T) double helix: wobble base pairs, Nucleic Acids Research, Volume 5, Issue 6, 1 June 1978, Pages 1955–1970, https://doi.org/10.1093/nar/5.6.1955
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Abstract

High resolution nuclear magnetic resonance (NMR) and ethidium bromide binding studies are used to demonstrate that poly d(G-T) forms an ordered double helical structure at low temperatures (below 24°C in 0.3 M NaCl) in which G and T are hydrogen bonded together in a wobble base pair hydrogen bonding scheme as proposed earlier by Lezius and Domin 1 . Alternative hydrogen bonding schemes involving the tautomeric form of either T or G, such as have been proposed to account for mutation rates in DNA synthesis, are eliminated.

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