A T to A base substitution and small deletions in the conalbumin TATA box drastically decrease specific in vitro transcription (original) (raw)
Journal Article
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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine
Strasbourg, France
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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine
Strasbourg, France
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Received:
17 February 1981
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B. Wasylyk, P. Chambon, A T to A base substitution and small deletions in the conalbumin TATA box drastically decrease specific in vitro transcription, Nucleic Acids Research, Volume 9, Issue 8, 24 April 1981, Pages 1813–1824, https://doi.org/10.1093/nar/9.8.1813
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Abstract
We have previously shown that a T to G transversion at the second T of the conalbumin “TATA” box drastically decreases specific initiation of transcription by RNA polymerase B (1). We now report that a T to A transition at the same nucleotide also drastically decreases transcription, suggesting that these mutations influence transcription mainly by altering nucleotide recognition rather than helix stability. Small deletions of 2, 3 and 4 nucleotides in the “TATA”box also drastically decrease specific initiation of transcription.
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