Systemic inflammation, metabolic syndrome and progressive renal disease (original) (raw)
Journal Article
Correspondence and offprint requests to : Pietro Cirillo, Division of Nephrology, Dialysis and Transplantation, Department of Biomedical Sciences, University of Foggia, College of Medicine, Viale L. Pinto 1, 71100, Foggia, Italy. Tel: +39-0881-732054 ; Fax:
+39-0881-736001
; E-mail: [email protected]
Search for other works by this author on:
1
Division of Nephrology, Hypertension and Transplantation, Department of Medicine
,
University of Florida
,
Gainesville, FL 32610
,
USA
Search for other works by this author on:
3
Department of Nephrology, Monash Medical Centre, Clayton, VIC 3168
,
Australia
Search for other works by this author on:
4
Department of Nephrology
,
Ewha Womans University School of Medicine
,
Seoul
,
Korea
Search for other works by this author on:
2
Division of Nephrology, Dialysis and Transplantation, Department of Biomedical Sciences
,
University of Foggia
,
Foggia
,
Italy
Search for other works by this author on:
5
Division of Renal Diseases and Hypertension
,
University of Colorado
,
Aurora, CO 80045
,
USA
Search for other works by this author on:
5
Division of Renal Diseases and Hypertension
,
University of Colorado
,
Aurora, CO 80045
,
USA
Search for other works by this author on:
Received:
29 December 2008
Accepted:
19 January 2009
Published:
10 February 2009
Cite
Pietro Cirillo, Yuri Y. Sautin, John Kanellis, Duk-Hee Kang, Loreto Gesualdo, Takahiko Nakagawa, Richard J. Johnson, Systemic inflammation, metabolic syndrome and progressive renal disease, Nephrology Dialysis Transplantation, Volume 24, Issue 5, May 2009, Pages 1384–1387, https://doi.org/10.1093/ndt/gfp038
Close
Navbar Search Filter Mobile Enter search term Search
Extract
Introduction
Systemic inflammation is a characteristic feature of metabolic syndrome and cardiovascular (CV) disease. One common marker used to define systemic inflammation is the plasma level of C-reactive protein (CRP) [ 1 ]. Studies by Ridker et al. have shown that subjects with elevated plasma CRP levels have an increased risk for CV death [ 2,3 ]. More recent studies have shown that an elevated CRP level may also increase the risk for CV events in patients with chronic kidney disease (CKD) [ 4 ]. Furthermore, an elevation in CRP also increases the risk for progression of kidney disease in subjects with CKD [ 5 ]. In addition, a number of therapeutic agents such as aspirin [ 6 ], statins [ 7,8 ], angiotensin converting enzyme (ACE) inhibitors [ 9 ] and antioxidants [ 10 ] have been reported to both reduce CRP levels and improve CV outcomes, thereby suggesting that reducing inflammation may provide a novel means for treating kidney disease. Therefore, understanding the mechanisms driving the inflammatory response, how it may mediate renal disease progression and how to prevent or treat this response is of great interest.
You do not currently have access to this article.
I agree to the terms and conditions. You must accept the terms and conditions.
Submit a comment
Name
Affiliations
Comment title
Comment
You have entered an invalid code
Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution's website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution's website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see "Sign in through society site" in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Systemic inflammation, metabolic syndrome and progressive renal disease - 24 Hours access
EUR €40.00
GBP £34.00
USD $44.00
Rental
This article is also available for rental through DeepDyve.
Advertisement intended for healthcare professionals
Advertisement intended for healthcare professionals