Klotho, phosphate and inflammation/ageing in chronic kidney disease (original) (raw)
Journal Article
1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
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1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
Search for other works by this author on:
Search for other works by this author on:
1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
Search for other works by this author on:
1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
Search for other works by this author on:
1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
Search for other works by this author on:
1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
3
Universidad Autónoma de Madrid
,
Madrid
,
Spain
4
Fundación Renal Iñigo Álvarez de Toledo-IRSIN, Madrid
,
Spain
Search for other works by this author on:
1
IIS-Fundación Jiménez Díaz
,
Madrid
,
Spain
3
Universidad Autónoma de Madrid
,
Madrid
,
Spain
4
Fundación Renal Iñigo Álvarez de Toledo-IRSIN, Madrid
,
Spain
Search for other works by this author on:
Published:
01 December 2012
Cite
María C. Izquierdo, María V. Perez-Gomez, María D. Sanchez-Niño, Ana B. Sanz, Olga Ruiz-Andres, Jonay Poveda, Juan Antonio Moreno, Jesús Egido, Alberto Ortiz, Klotho, phosphate and inflammation/ageing in chronic kidney disease, Nephrology Dialysis Transplantation, Volume 27, Issue suppl_4, December 2012, Pages iv6–iv10, https://doi.org/10.1093/ndt/gfs426
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Abstract
Evidence is emerging for the inflammatory nature of many ageing-associated diseases, including atherosclerosis, vascular calcification, diabetes and chronic kidney disease (CKD), among others. Ageing itself results in chronic low-grade inflammation that promotes end-organ damage. Inflammatory organ damage, in turn, may contribute to inflammation. Recent research has identified the kidney-secreted hormone Klotho as a central player at the ageing–inflammation interface. Thus, systemic or local renal inflammation decreases kidney Klotho expression. Klotho down-regulation may be induced by specific cytokines such as _tumour necrosis factor_-α or TWEAK through the canonical activation of the inflammatory transcription factor nuclear factor kappa B (NFκB) and, specifically RelA. In addition, inflammatory cytokines lead to the epigenetic inactivation of Klotho transcription. Klotho itself has antioxidant and anti-inflammatory properties and the canonical NFκB component RelA is one of its targets. Klotho is a key regulator of phosphate balance and a role of phosphate in ageing has been shown. However, the potential relationship between phosphate and inflammation requires further clarification. A correct understanding of these interactions may lead to the design of novel therapeutic approaches to CKD and CKD-related inflammatory and ageing features as well as to inflammation/ageing in general.
© The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: [email protected]
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