Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study (original) (raw)

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1

Department of Health Sciences Research, Mayo Clinic and Mayo Foundation

Rochester, MN

Reprint requests to Dr. Cynthia Leibson, Harwick 655, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905.

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Department of Health Sciences Research, Mayo Clinic and Mayo Foundation

Rochester, MN

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Department of Health Sciences Research, Mayo Clinic and Mayo Foundation

Rochester, MN

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Department of Health Sciences Research, Mayo Clinic and Mayo Foundation

Rochester, MN

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Department of Neurology, Mayo Clinic and Mayo Foundation

Rochester, MN

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Department of Health Sciences Research, Mayo Clinic and Mayo Foundation

Rochester, MN

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Department of Endocrinology, Mayo Clinic and Mayo Foundation

Scottsdale, AZ

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Accepted:

02 October 1996

Published:

15 February 1997

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C. L Leibson, W. A. Rocca, V. A. Hanson, R. Cha, E. Kokmen, P. C. O'Brien, P. J. Palumbo, Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study, American Journal of Epidemiology, Volume 145, Issue 4, 15 February 1997, Pages 301–308, https://doi.org/10.1093/oxfordjournals.aje.a009106
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Abstract

It is unclear whether persons with diabetes are at increased risk for dementia, including Alzheimer's disease. Existing studies are limited by small sample size, selection bias, and case-control designs. This population-based historical cohort study provides estimates of the risk of dementia and Alzheimer's disease associated with adult onset diabetes mellitus (AODM). The sample included all persons with AODM residing in Rochester, Minnesota, on January 1, 1970, plus all persons diagnosed in Rochester or who moved to Rochester with the diagnosis between January 1, 1970, and December 31, 1984. Individuals were followed through review of their complete medical records from AODM diagnosis until dementia onset, emigration, death, or January 1, 1985. Standardized morbidity ratios for dementia and Alzheimer's disease were calculated, using an expected incidence based on age- and sex-specific rates for the Rochester population. Poisson regression was used to estimate risks for persons with AODM relative to those without. Of the 1, 455 cases of AODM followed for 9,981 person-years, 101 developed dementia, including 77 who met criteria for Alzheimer's disease. Persons with AODM exhibited significantly increased risk of all dementia (Poisson regression relative risk (RR) = 1.66, 95% confidence interval (Cl) 1.34–2.05). Risk of Alzheimer's disease was also elevated (for men, RR = 2.27, 95% Cl 1.55–3.31; for women, RR = 1.37, 95% Cl 0.94–2.01). These findings emphasize the importance of AODM prevention and prompt additional investigation of the relation between AODM and dementia. Am J Epidemiol 1997; 145: 301–8.

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© 1997 by The Johns Hopkins University School of Hygiene and Public Health

Topic:

• diabetes mellitus
• medical records
• alzheimer's disease
• diabetes mellitus, type 2
• dementia
• diagnosis
• morbidity
• prevention
• symptom onset

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