Genetic Insights Into the Neurodevelopmental Hypothesis of Schizophrenia (original) (raw)

Journal Article

,

Anne S. Bassett, M.D., FRCPC

Associate Professor

Department of Psychiatry, University of Toronto

, and Head,

Genetics Section, Schizophrenia Research Program, Queen Street Division, Centre for Addiction and Mental Health

Toronto, Ontario

Send reprint requests to: Dr. A.S. Bassett, Schizophrenia Research Program, Queen Street Site, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario, Canada, M6J 1H4; e-mail: anne.bassett@utoronto.ca

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,

Eva W.C. Chow, M.D., FRCPC

Assistant Professor

Department of Psychiatry, University of Toronto and Centre for Addiction and Mental Health

Toronto, Ontario

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,

Sheri O'Neill, M.Sc., CCGC

Genetic Counselor

Schizophrenia Research Program, Queen Street Division, Centre for Addiction and Mental Health

Toronto, Ontario

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Linda M. Brzustowicz, M.D.

Assistant Professor

Department of Genetics, Rutgers University, Piscataway, and Department of Psychiatry, University of Medicine and Dentistry of New Jersey

Newark/Piscataway, NJ

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Published:

01 January 2001

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Anne S. Bassett, Eva W.C. Chow, Sheri O'Neill, Linda M. Brzustowicz, Genetic Insights Into the Neurodevelopmental Hypothesis of Schizophrenia, Schizophrenia Bulletin, Volume 27, Issue 3, 2001, Pages 417–430, https://doi.org/10.1093/oxfordjournals.schbul.a006884
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Abstract

The original neurodevelopmental hypothesis of schizophrenia presented by D.R. Weinberger in 1987 focused on pathogenesis and did not address etiology. Available evidence indicates that genetic factors are the principal cause of schizophrenia. It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. Recent advances in molecular genetics can provide insights into the neurodevelopmental expression of the illness and what future genetic discoveries are likely to contribute to our understanding of schizophrenia. In this article, we propose a genetic model of etiopathogenesis that is consistent both with a modified neurodevelopmental hypothesis and our current knowledge about schizophrenia and molecular genetics.

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Topic:

• genetics, molecular
• models, genetic
• schizophrenia
• genetics
• genetic aspects
• causality

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