Increased Myogenic Responses in Uterine but not Mesenteric Arteries from Pregnant Offspring of Diet-Restricted Rat Dams1 (original) (raw)

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4Department of Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta Canada, T6G 2S2

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4Department of Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta Canada, T6G 2S2

5Maternal and Fetal Health Research Centre, University of Manchester, St. Mary’s Hospital, Whitworth Park, Manchester M13 0JH, United Kingdom

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5Maternal and Fetal Health Research Centre, University of Manchester, St. Mary’s Hospital, Whitworth Park, Manchester M13 0JH, United Kingdom

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4Department of Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta Canada, T6G 2S2

2Correspondence: Sandra T. Davidge, Perinatal Research Centre, 220 Heritage Medical Research Centre, University of Alberta, Edmonton, AB T6G 2S2, Canada. FAX 780 492 1308;

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Revision received:

29 September 2004

Accepted:

07 December 2004

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Denise G. Hemmings, Sukrutha Veerareddy, Philip N. Baker, Sandra T. Davidge, Increased Myogenic Responses in Uterine but not Mesenteric Arteries from Pregnant Offspring of Diet-Restricted Rat Dams, Biology of Reproduction, Volume 72, Issue 4, 1 April 2005, Pages 997–1003, https://doi.org/10.1095/biolreprod.104.035675
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Abstract

Results of epidemiological and animal studies suggest a link between poor in utero growth and cardiovascular disease in adult offspring. Few studies, however, have examined the effects of maternal undernutrition on the vasculature of pregnant female offspring, and to our knowledge, no studies have examined myogenic responses, which are essential to vascular tone development, in these animal models. Thus, myogenic responses were assessed in radial uterine arteries of pregnant female offspring to determine if diet restriction during pregnancy could contribute to transgenerational effects. These results were compared to those in mesenteric arteries, which greatly contribute to peripheral vascular resistance. Myogenic responses in the presence and absence of inhibitors for nitric oxide synthase (NOS) and prostaglandin H synthase (PGHS) were measured in arteries isolated from pregnant, 3-mo-old female offspring of control-fed (Coff) and globally diet-restricted (DRoff) rat dams. Although no differences were found in pregnancy weight gain, litter size, or fetal weights, placental size was significantly reduced in DRoff compared to Coff. Enhanced myogenic reactivity was observed at the highest pressure tested (110 mm Hg) in uterine, but not in mesenteric, arteries from DRoff compared to Coff. Inhibition of NOS, but not of PGHS, significantly increased myogenic responses in uterine arteries at pressures greater than 80 mm Hg in Coff but, interestingly, not in DRoff compared to untreated uterine arteries. Thus, impaired uterine vascular function in diet-restricted pregnant rat dams, which leads to similar impairment in their pregnant offspring, may be a mechanism through which transgenerational effects of unhealthy pregnancies occur.

© 2005 by the Society for the Study of Reproduction, Inc.

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