Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders (original) (raw)

Journal Article

,

Neuroepidemiology Branch,

National Institute of Neurological Disorders and Stroke

, Bethesda, Maryland, USA

Correspondence to: Irene Litvan, MD, Federal Building, Room 714, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Search for other works by this author on:

,

Raymond Escourolle Neuropathology Laboratory, INSERM U 360, Association Claude Bernard,

Hôpital de la Salpêtriêre

, Paris, France

Search for other works by this author on:

,

Division of Epidemiology and Research Studies,

National Institute of Mental Health

, Bethesda, Maryland, USA

Search for other works by this author on:

,

Department of Neuropathology,

Institute of Psychiatry

, London, UK

Search for other works by this author on:

,

Parkinson's Disease Society Brain Tissue Bank and Department of Neuropathology,

Institute of Neurology

, London, UK

Search for other works by this author on:

,

Department of Pathology (Neuropathology),

Stanford School of Medicine

, Stanford, California, USA

Search for other works by this author on:

,

Department of Neuropathology,

Massachusetts General Hospital

, Boston, Massachusetts, USA

Search for other works by this author on:

,

Department of Neuropathology,

Albert Einstein College of Medicine

, Bronx, New York, USA

Search for other works by this author on:

,

Ludwig Boltzmann Institute of Clinical Neurobiology

, Vienna, Austria

Search for other works by this author on:

,

Division of Neuropathology,

Case Western Reserve University

, Cleveland, Ohio, USA

Search for other works by this author on:

... Show more

Dr Daniel was supported by a grant from the Parkinson's Disease Society of the United Kingdom. Prof. Lantos received support from the Medical Research Council, United Kingdom.

Presented in part at the 119th Annual Meeting of the American Neurological Association, San Francisco, California, October 11, 1994, and at the Annual Meeting of the World Federation of Neurology, Bethesda, Maryland, May 6, 1994.

Author Notes

Published:

01 January 1996

• PDF
• Split View
• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

I. Litvan, J.J. Hauw, J.J. Bartko, P.L. Lantos, S.E. Daniel, D.S. Horoupian, A. McKee, D. Dickson, C. Bancher, M. Tabaton, K. Jellinger, D.W. Anderson, Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders, Journal of Neuropathology & Experimental Neurology, Volume 55, Issue 1, January 1996, Pages 97–105, https://doi.org/10.1097/00005072-199601000-00010
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

We investigated the validity and reliability of diagnoses made by eight neuropathologists who used the preliminary NINDS neuropathologic diagnostic criteria for progressive supranuclear palsy (PSP) and related disorders. The specific disorders were typical, atypical, and combined PSP, postencephalitic parkinsonism, corticobasal ganglionic degeneration, and Pick's disease. These disorders were chosen because of the difficulties in their neuropathologic differentiation. We assessed validity by measuring sensitivity and positive predictive value. Reliability was evaluated by measuring pairwise and group agreement. From a total of 62 histologic cases, each neuropathologist independently classified 16 to 19 cases for the pairwise analysis and 5 to 6 cases for the group analysis. The neuropathologists were unaware of the study design, unfamiliar with the assigned cases, and initially had no clinical information about the cases. Our results showed that with routine sampling and staining methods, neuropathologic examination alone was not fully adequate for differentiating the disorders. The main difficulties were discriminating the subtypes of PSP and separating postencephalitic parkinsonism from PSP. Corticobasal ganglionic degeneration and Pick's disease were less difficult to distinguish from PSP. The addition of minimal clinical information contributed to the accuracy of the diagnosis. On the basis of results obtained, we propose clinicopathologic diagnostic criteria to improve on the NINDS criteria.

This content is only available as a PDF.

Author notes

Dr Daniel was supported by a grant from the Parkinson's Disease Society of the United Kingdom. Prof. Lantos received support from the Medical Research Council, United Kingdom.

Presented in part at the 119th Annual Meeting of the American Neurological Association, San Francisco, California, October 11, 1994, and at the Annual Meeting of the World Federation of Neurology, Bethesda, Maryland, May 6, 1994.

© 1996, by the American Association of Neuropathologists, Inc.

Topic:

• ganglia
• parkinson disease, postencephalitic
• dementia due to pick's disease
• progressive supranuclear palsy
• diagnosis
• national institute of neurological disorders and stroke
• tissue degeneration
• neuropathology

Citations

Views

Altmetric

Metrics

Total Views 1,170

84 Pageviews

1,086 PDF Downloads

Since 1/1/2017

Citations

435 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic