Impact of White Matter Changes on Activities of Daily Living in Mild to Moderate Dementia (original) (raw)
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Research Articles| March 30 2011
aDepartment of Neurology, Ajou University School of Medicine, Suwon,
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bDepartment of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul,
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bDepartment of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul,
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cDepartment of Psychiatry, Seoul National University Boramae Hospital, Seoul,
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dDepartment of Neurology, College of Medicine, Kwandong University, Myongji Hospital, Ko-yang,
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eDepartment of Psychiatry, Asan Medical Center, University of Ulsan, College of Medicine, Seoul,
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fDepartment of Neurology, Dong-A University College of Medicine, Busan,
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gDepartment of Neurology, Bucheon St. Mary’s Hospital, The Catholic University of Korea, School, Bucheon,
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hDepartment of Neurology, College of Medicine, Chung-Ang University, Seoul,
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iDepartment of Psychiatry, Hyowon Geriatric Hospital, Yong-in,
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jDepartment of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Seoul,
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kDepartment of Neurology, Inha University College of Medicine, Incheon,
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lDepartment of Psychiatry, MunGyeong Jeil General Hospital, Mungyeong, and
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mDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea
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mDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea
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Eur Neurol (2011) 65 (4): 223–230.
Citation
So Young Moon, Duk L. Na, Sang Won Seo, Jun-Young Lee, Bon D. Ku, Seong Yoon Kim, Kyung Won Park, Yong S. Shim, Young Chul Youn, Chan-Seung Chung, Hae-Kwan Cheong, Seong Hye Choi, Kyung Ryeol Cha, Jung-Eun Kim, Jee H. Jeong; Impact of White Matter Changes on Activities of Daily Living in Mild to Moderate Dementia. _Eur Neurol 1 April 2011; 65 (4): 223–230. https://doi.org/10.1159/000318161
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Abstract
The association between white matter changes and activities of daily living (ADL) in a large, well-defined cohort of patients with mild-to-moderate dementia (either Alzheimer’s disease or subcortical vascular dementia) were investigated. A total of 289 patients were divided into three groups (140 mild, 99 moderate, and 50 severe) depending on the degree of white matter changes as indicated on brain magnetic resonance image scans. Further, we analyzed the three groups’ performances on basic and instrumental ADL. The degree of white matter changes was associated with greater age, hypertension, previous history of stroke, higher Hachinski Ischemic Score, worse global cognitive and functional status, and an increased impairment of basic ADL and instrumental ADL. The increased impairment with regard to the severe group’s performance on both the basic and instrumental ADL remained significant after adjustment for age and hypertension. Tasks involving physical activities were most significant. This was the first study investigating the association between white matter changes and ADL in a large, well-defined dementia cohort. The present study suggests that severe white matter changes may be associated with higher impairment on both basic and instrumental ADL.
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