Frailty and Associated Factors among Centenarians in the 5-COOP Countries (original) (raw)
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Research Articles| July 20 2018
aINSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France
bUniversité de Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France
cDépartement Hospitalier d’Epidémiologie et Santé Publique, Hôpitaux Universitaires Paris Ile-de-France Ouest, Assistance Publique-Hôpitaux de Paris, Paris, France
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dEpidemiology and Biostatistics, Institute of Public Health, and Danish Aging Research Centre, University of Southern Denmark, Odense, Denmark
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eAging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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dEpidemiology and Biostatistics, Institute of Public Health, and Danish Aging Research Centre, University of Southern Denmark, Odense, Denmark
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aINSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France
bUniversité de Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France
cDépartement Hospitalier d’Epidémiologie et Santé Publique, Hôpitaux Universitaires Paris Ile-de-France Ouest, Assistance Publique-Hôpitaux de Paris, Paris, France
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fCenter for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan
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gMMDN, Université de Montpellier, EPHE, INSERM, U1198, PSL Research University, Montpellier, France
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hLausanne University Hospital, Institute of Social and Preventive Medicine, Lausanne, Switzerland
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iDivision of Geriatrics, Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
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eAging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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jUniversity Research Center, Nihon University, Tokyo, Japan
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iDivision of Geriatrics, Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
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gMMDN, Université de Montpellier, EPHE, INSERM, U1198, PSL Research University, Montpellier, France
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Gerontology (2018) 64 (6): 521–531.
Citation
Marie Herr, Bernard Jeune, Stefan Fors, Karen Andersen-Ranberg, Joël Ankri, Yasu Arai, Sarah Cubaynes, Brigitte Santos-Eggimann, Dina Zekry, Marti Parker, Yasuhiko Saito, François Herrmann, Jean-Marie Robine, 5-COOP group; Frailty and Associated Factors among Centenarians in the 5-COOP Countries. _Gerontology 16 October 2018; 64 (6): 521–531. https://doi.org/10.1159/000489955
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Abstract
Background: The global number of centenarians is still strongly growing and information about the health and healthcare needs of this segment of the population is needed. This study aimed to estimate the prevalence of frailty among centenarians included in a multinational study and to investigate associated factors. Methods: The 5-COOP study is a cross-sectional survey including 1,253 centenarians in 5 countries (Japan, France, Switzerland, Denmark, and Sweden). Data were collected using a standardized questionnaire during a face-to-face interview (73.3%), telephone interview (14.5%), or by postal questionnaire (12.2%). The 5 dimensions of the frailty phenotype (weight loss, fatigue, weakness, slow walking speed, and low level of physical activity) were assessed by using self-reported data. Factors associated with frailty criteria were investigated by using multivariate regression models. Results: Almost 95% of the participants had at least 1 frailty criterion. The overall prevalence of frailty (3 criteria or more) was 64.7% (from 51.5% in Sweden to 77.6% in Switzerland), and 32.2% of the participants had 4 or 5 criteria. The most frequent criteria were weakness (84.2%), slow walking speed (77.6%), and low level of physical activity (72.5%), followed by fatigue (43.8%) and weight loss (23.8%). Factors associated with frailty included data collection modes, country of residence, gender, living in institution, depression, dementia, disability, falls, and sensory impairments. Conclusions: This study shows that reaching 100 years of age rarely goes without frailty and sheds light on factors associated with frailty at a very old age.
References
Robine JM, Cubaynes S: Worldwide demography of centenarians. Mech Ageing Dev 2017; 165: 59–67.
Robine JM, Cambois E, Nusselder W, Jeune B, Oyen HV, Jagger C; JA: EHLEIS team: The joint action on healthy life years (JA: EHLEIS). Arch Public Health 2013; 71: 72.
Rowe JW, Kahn RL: Human aging: usual and successful. Science 1987; 237: 143–149.
Gill TM, Gahbauer EA, Han L, Allore HG: Trajectories of disability in the last year of life. N Engl J Med 2010; 362: 1173–1180.
Christensen K, Thinggaard M, Oksuzyan A, Steenstrup T, Andersen-Ranberg K, Jeune B, McGue M, Vaupel JW: Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart. Lancet 2013; 382: 1507–1513.
Rasmussen SH, Thinggaard M, Hojgaard MB, Jeune B, Christensen K, Andersen-Ranberg K: Improvement in activities of daily living among Danish centenarians? J Gerontol A Biol Sci Med Sci 2017, Epub ahead of print.
Herr M, Arvieu JJ, Robine JM, Ankri J: Health, frailty and disability after ninety: results of an observational study in France. Arch Gerontol Geriatr 2016; 66: 166–175.
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A: A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489–495.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA: Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56:M146–M156.
Sirven N, Rapp T: The cost of frailty in France. Eur J Health Econ 2017; 18: 243–253.
Sirven N, Rapp T: The dynamics of hospital use among older people evidence for Europe using SHARE data. Health Serv Res 2017; 52: 1168–1184.
Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, Wolfson C: Frailty: an emerging research and clinical paradigm – issues and controversies. J Gerontol A Biol Sci Med Sci 2007; 62: 731–737.
Shamliyan T, Talley KM, Ramakrishnan R, Kane RL: Association of frailty with survival: a systematic literature review. Ageing Res Rev 2013; 12: 719–736.
Herrmann FR, Osiek A, Cos M, Michel JP, Robine JM: Frailty judgment by hospital team members: degree of agreement and survival prediction. J Am Geriatr Soc 2005; 53: 916–917.
Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Gutierrez Robledo LM, Rockwood K, von Haehling S, Vandewoude MF, Walston J: Frailty consensus: a call to action. J Am Med Dir Assoc 2013; 14: 392–397.
Puts MT, Toubasi S, Andrew MK, Ashe MC, Ploeg J, Atkinson E, Ayala AP, Roy A, Rodriguez Monforte M, Bergman H, McGilton K: Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing 2017; 46: 383–392.
Dartigues JF: Methodological problems in clinical and epidemiological research on ageing (in French). Rev Epidemiol Sante Publique 2005; 53: 243–249.
Collard RM, Boter H, Schoevers RA, Oude Voshaar RC: Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 2012; 60: 1487–1492.
Gu D, Feng Q: Frailty still matters to health and survival in centenarians: the case of China. BMC Geriatr 2015; 15: 159.
Kwan JS, Lau BH, Cheung KS: Toward a comprehensive model of frailty: an emerging concept from the Hong Kong Centenarian Study. J Am Med Dir Assoc 2015; 16: 536 e1–e7.
Ferrer A, Badia T, Formiga F, Sanz H, Megido MJ, Pujol R: Frailty in the oldest old: prevalence and associated factors. J Am Geriatr Soc 2013; 61: 294–296.
Kojima G, Iliffe S, Taniguchi Y, Shimada H, Rakugi H, Walters K: Prevalence of frailty in Japan: a systematic review and meta-analysis. J Epidemiol 2017; 27: 347–353.
Duarte N, Teixeira L, Ribeiro O, Paul C: Frailty phenotype criteria in centenarians: findings from the Oporto Centenarian Study. Eur Geriatr Med 2014; 5: 371–376.
Robine JM, Cheung SL, Saito Y, Jeune B, Parker MG, Herrmann FR: Centenarians today: new insights on selection from the 5-COOP study. Curr Gerontol Geriatr Res 2010; 2010: 120354.
Kontis V, Bennett JE, Mathers CD, Li G, Foreman K, Ezzati M: Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet 2017; 389: 1323–1335.
Herr M, Robine JM, Pinot J, Arvieu JJ, Ankri J: Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people. Pharmacoepidemiol Drug Saf 2015; 24: 637–646.
Santos-Eggimann B, Cuenoud P, Spagnoli J, Junod J: Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries. J Gerontol A Biol Sci Med Sci 2009; 64: 675–681.
Herr M, Robine JM, Aegerter P, Arvieu JJ, Ankri J: Contribution of socioeconomic position over life to frailty differences in old age: comparison of life-course models in a French sample of 2350 old people. Ann Epidemiol 2015; 25: 674–680 e1.
Linard M, Herr M, Aegerter P, Czernichow S, Goldberg M, Zins M, Ankri J: Should sensory impairment be considered in frailty assessment? A study in the GAZEL cohort. J Nutr Health Ageing 2016; 20: 714–721.
Vestergaard S, Andersen-Ranberg K, Skytthe A, Christensen K, Robine JM, Jeune B: Health and function assessments in two adjacent Danish birth cohorts of centenarians: impact of design and methodology. Eur J Ageing 2016; 13: 15–23.
Sutton JL, Gould RL, Daley S, Coulson MC, Ward EV, Butler AM, Nunn SP, Howard RJ: Psychometric properties of multicomponent tools designed to assess frailty in older adults: a systematic review. BMC Geriatr 2016; 16: 55.
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2018
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