G-protein-coupled receptor expression, function, and signaling in macrophages (original) (raw)

Journal Article

,

Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland

,

Brisbane, Queensland

,

Australia

Search for other works by this author on:

,

Division of Cardiology, Duke University Medical Center

,

Durham, North Carolina

,

USA

Search for other works by this author on:

,

Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland

,

Brisbane, Queensland

,

Australia

Search for other works by this author on:

,

Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland

,

Brisbane, Queensland

,

Australia

School of Molecular and Microbial Sciences, University of Queensland

,

Brisbane, Queensland

,

Australia

Search for other works by this author on:

,

Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland

,

Brisbane, Queensland

,

Australia

Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland

,

Brisbane, Queensland

,

Australia

Search for other works by this author on:

Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland

,

Brisbane, Queensland

,

Australia

School of Molecular and Microbial Sciences, University of Queensland

,

Brisbane, Queensland

,

Australia

Correspondence: Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. E-mail: m.sweet@imb.uq.edu.au

Search for other works by this author on:

Received:

22 January 2007

Revision received:

29 March 2007

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Jane Lattin, David A Zidar, Kate Schroder, Stuart Kellie, David A Hume, Matthew J Sweet, G-protein-coupled receptor expression, function, and signaling in macrophages, Journal of Leukocyte Biology, Volume 82, Issue 1, July 2007, Pages 16–32, https://doi.org/10.1189/jlb.0107051
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage-restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GPCR-independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage.

© 2007 Society for Leukocyte Biology

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

G-protein-coupled receptor expression, function, and signaling in macrophages - 24 Hours access

EUR €48.00

GBP £41.00

USD $51.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 186

119 Pageviews

67 PDF Downloads

Since 2/1/2023

Citations

91 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic