Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection (original) (raw)

Journal Article

,

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Search for other works by this author on:

,

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Search for other works by this author on:

,

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Search for other works by this author on:

,

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Search for other works by this author on:

,

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Search for other works by this author on:

,

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Search for other works by this author on:

Department of Immunology, University of Connecticut Health Center

, Farmington, Connecticut,

USA

Correspondence: Dept. of Immunology, University of Connecticut Health Center, L3062, 263 Farmington Ave., Farmington, CT 06032, USA. E-mail: lcauley@uchc.edu

Search for other works by this author on:

Revision received:

11 July 2013

Published:

04 September 2013

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Tao Wu, Yinghong Hu, Young-Tae Lee, Keith R Bouchard, Alexandre Benechet, Kamal Khanna, Linda S Cauley, Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection, Journal of Leukocyte Biology, Volume 95, Issue 2, Feb 2014, Pages 215–224, https://doi.org/10.1189/jlb.0313180
Close

Navbar Search Filter Mobile Enter search term Search

ABSTRACT

Previous studies have shown that some respiratory virus infections leave local populations of tissue TRM cells in the lungs which disappear as heterosubtypic immunity declines. The location of these TRM cells and their contribution to the protective CTL response have not been clearly defined. Here, fluorescence microscopy is used to show that some CD103+ TRM cells remain embedded in the walls of the large airways long after pulmonary immunization but are absent from systemically primed mice. Viral clearance from the lungs of the locally immunized mice precedes the development of a robust Teff response in the lungs. Whereas large numbers of virus-specific CTLs collect around the bronchial tree during viral clearance, there is little involvement of the remaining lung tissue. Much larger numbers of TEM cells enter the lungs of the systemically immunized animals but do not prevent extensive viral replication or damage to the alveoli. Together, these experiments show that virus-specific antibodies and TRM cells are both required for optimal heterosubtypic immunity, whereas circulating memory CD8 T cells do not substantially alter the course of disease.

© 2014 Society for Leukocyte Biology

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open\_access/funder\_policies/chorus/standard\_publication\_model)

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection - 24 Hours access

EUR €48.00

GBP £41.00

USD $51.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 657

431 Pageviews

226 PDF Downloads

Since 2/1/2023

Citations

379 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic