HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation (original) (raw)

Journal Article

,

Laboratory of Immunobiology, Institute of Biomedicine

, Campus de Vegazana s/n, Leon,

Spain

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Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School

, Boston, Massachusetts,

USA

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Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School

, Boston, Massachusetts,

USA

Surgical Research Unit, Department of Surgery, University Hospital Geneva

, Geneva,

Switzerland

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Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta

, Edmonton, Alberta,

Canada

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Laboratory of Immunobiology, Institute of Biomedicine

, Campus de Vegazana s/n, Leon,

Spain

Correspondence: Institute of Biomedicine (Immunobiology), University of Leon, Campus de Vegazana s/n, 24071-Leon, Spain. E-mail: ignacio.barbosa@unileon.es

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Revision received:

26 October 2009

Accepted:

29 October 2009

Published:

09 December 2009

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M L del Rio, C L Lucas, L Buhler, G Rayat, J I Rodriguez-Barbosa, HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation, Journal of Leukocyte Biology, Volume 87, Issue 2, Feb 2010, Pages 223–235, https://doi.org/10.1189/jlb.0809590
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Abstract

This review highlights how the blockade of the co-stimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses.

Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threatening infections and is associated with organ toxicity when used long-term. Thus, alternative approaches that inhibit only the unwanted immune responses and preserve general immunity are highly desirable. The receptor/ligand pairs involved in the cross-talk between DC and T cells have been the focus of intense and exciting research during the last decade. The HVEM/LIGHT/BTLA/CD160 costimulatory/coinhibitory pathway has emerged as a potential target for the development of immune therapeutic interventions. Herein, we will summarize and discuss how blockade of the costimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses.

© 2010 Society for Leukocyte Biology

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

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