Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction (original) (raw)
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1Chair of Clinical Immunology and Allergy (C.B., C.D.P., R.Z.), Department of Medical and Surgical Sciences, University of Padova, I-35128, Padova, Italy
*Address all correspondence and requests for reprints to: Professor Corrado Betterle, M.D., Chair of Clinical Immunology and Allergy, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale 105, 35128 Padova, Italy.
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1Chair of Clinical Immunology and Allergy (C.B., C.D.P., R.Z.), Department of Medical and Surgical Sciences, University of Padova, I-35128, Padova, Italy
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2Chair and Division of Endocrinology (F.M.), Department of Medical and Surgical Sciences, University of Padova, I-35128, Padova, Italy
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1Chair of Clinical Immunology and Allergy (C.B., C.D.P., R.Z.), Department of Medical and Surgical Sciences, University of Padova, I-35128, Padova, Italy
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Corrado Betterle, Chiara Dal Pra, Franco Mantero, Renato Zanchetta, Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction, Endocrine Reviews, Volume 23, Issue 3, 1 June 2002, Pages 327–364, https://doi.org/10.1210/edrv.23.3.0466
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Abstract
Recent progress in the understanding of autoimmune adrenal disease, including a detailed analysis of a group of patients with Addison’s disease (AD), has been reviewed. Criteria for defining an autoimmune disease and the main features of autoimmune AD (history, prevalence, etiology, histopathology, clinical and laboratory findings, cell-mediated andhumoral immunity, autoantigens and their autoepitopes, genetics, animal models, associated autoimmune diseases, pathogenesis, natural history, therapy) have been described. Furthermore, the autoimmune polyglandular syndromes (APS) associated with AD (revised classification, animal models, genetics, natural history) have been discussed.
Of Italian patients with primary AD (n = 317), 83% had autoimmune AD. At the onset, all patients with autoimmune AD (100%) had detectable adrenal cortex and/or steroid 21-hydroxylase autoantibodies. In the course of natural history of autoimmune AD, the presence of adrenal cortex and/or steroid 21-hydroxylase autoantibodies identified patients at risk to develop AD. Different risks of progression to clinical AD were found in children and adults, and three stages of subclinical hypoadrenalism have been defined. Normal or atrophic adrenal glands have been demonstrated by imaging in patients with clinical or subclinical AD.
Autoimmune AD presented in four forms: as APS type 1 (13% of the patients), APS type 2 (41%), APS type 4 (5%), and isolated AD (41%). There were differences in genetics, age at onset, prevalence of adrenal cortex/21-hydroxylase autoantibodies, and associated autoimmune diseases in these groups. “Incomplete” forms of APS have been identified demonstrating that APS are more prevalent than previously reported.
A varied prevalence of hypergonadotropic hypogonadism in patients with AD and value of steroid-producing cells autoantibodies reactive with steroid 17α-hydroxylase or P450 side-chain cleavage enzyme as markers of this disease has been discussed. In addition, the prevalence, characteristic autoantigens, and autoantibodies of minor autoimmune diseases associated with AD have been described.
Imaging of adrenal glands, genetic tests, and biochemical analysis have been shown to contribute to early and correct diagnosis of primary non-autoimmune AD in the cases of hypoadrenalism with undetectable adrenal autoantibodies. An original flow chart for the diagnosis of AD has been proposed.
Copyright © 2002 by The Endocrine Society
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