Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition (original) (raw)

Journal Article

,

1Laboratory of Neuroendocrinology, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh (A.J.D., P.J.B., J.A.R.), Edinburgh, United Kingdom EH8 9XD

*Address all correspondence and requests for reprints to: Dr. Alison J. Douglas, Division of Biomedical Sciences, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, United Kingdom EH8 9XD.

Search for other works by this author on:

,

1Laboratory of Neuroendocrinology, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh (A.J.D., P.J.B., J.A.R.), Edinburgh, United Kingdom EH8 9XD

Search for other works by this author on:

,

2Institute of Zoology, University of Regensburg (O.J.B., I.D.N.), 93040 Regensburg, Germany

Search for other works by this author on:

,

1Laboratory of Neuroendocrinology, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh (A.J.D., P.J.B., J.A.R.), Edinburgh, United Kingdom EH8 9XD

Search for other works by this author on:

2Institute of Zoology, University of Regensburg (O.J.B., I.D.N.), 93040 Regensburg, Germany

Search for other works by this author on:

Published:

01 December 2003

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Alison J. Douglas, Paula J. Brunton, Oliver J. Bosch, John A. Russell, Inga D. Neumann, Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition, Endocrinology, Volume 144, Issue 12, 1 December 2003, Pages 5268–5276, https://doi.org/10.1210/en.2003-0461
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Hypothalamo-pituitary-adrenal axis secretory responses to stress were compared in female virgin, late pregnant, parturient, and lactating mice. The basal plasma ACTH concentration was not different in pregnancy or lactation compared with virgins, but corticosterone concentration and corticosteroid-binding globulin capacity were greatly elevated in late pregnancy. Secretory responses to novel environment were attenuated in pregnant, but not lactating, mice compared with virgin females, whereas ACTH responses to forced swimming were attenuated in both groups. The expression of immediate early gene (nur77) mRNA increased in paraventricular nucleus neurons after stress exposure in virgin and lactating, but not pregnant, mice. During parturition, the basal ACTH concentration was similar to virgin and pregnant controls and did not increase with stress. Oxytocin secretion in response to either novel environment or forced swimming was unchanged in any reproductive group, whereas vasopressin secretion was decreased by both stressors, but only in virgins. Pretreatment with oxytocin receptor antagonist centrally had no effect on ACTH responses to stress in either virgin or pregnant mice. Pretreatment with an opioid receptor antagonist increased ACTH responses to stress in virgin mice, indicating opioid inhibition, but had no effect in pregnancy. Thus, in mice hypothalamo-pituitary-adrenal hyporesponsiveness in late pregnancy is a consequence of reduced responsiveness of paraventricular neurons, but inhibition by opioids or intracerebral oxytocin does not appear to be involved.

Copyright © 2003 by The Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 2,896

1,868 Pageviews

1,028 PDF Downloads

Since 1/1/2017

Citations

109 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic