Antiobesity Effects of the β-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression (original) (raw)
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1Amylin Pharmaceuticals, Inc., San Diego, California 92121
*Address all correspondence and requests for reprints to: Jonathan D. Roth, Ph.D., Amylin Pharmaceuticals, Inc., San Diego, California 92121.
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1Amylin Pharmaceuticals, Inc., San Diego, California 92121
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1Amylin Pharmaceuticals, Inc., San Diego, California 92121
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1Amylin Pharmaceuticals, Inc., San Diego, California 92121
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1Amylin Pharmaceuticals, Inc., San Diego, California 92121
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Published:
01 December 2006
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Jonathan D. Roth, Heather Hughes, Eric Kendall, Alain D. Baron, Christen M. Anderson, Antiobesity Effects of the β-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression, Endocrinology, Volume 147, Issue 12, 1 December 2006, Pages 5855–5864, https://doi.org/10.1210/en.2006-0393
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Effects of amylin and pair feeding (PF) on body weight and metabolic parameters were characterized in diet-induced obesity-prone rats. Peripherally administered rat amylin (300 μg/kg·d, 22d) reduced food intake and slowed weight gain: approximately 10% (P < 0.05), similar to PF. Fat loss was 3-fold greater in amylin-treated rats vs. PF (P < 0.05). Whereas PF decreased lean tissue (P < 0.05 vs. vehicle controls; VEH), amylin did not. During wk 1, amylin and PF reduced 24-h respiratory quotient (mean ± se, 0.82 ± 0.0, 0.81 ± 0.0, respectively; P < 0.05) similar to VEH (0.84 ± 0.01). Energy expenditure (EE mean ± se) tended to be reduced by PF (5.67 ± 0.1 kcal/h·kg) and maintained by amylin (5.86 ± 0.1 kcal/h·kg) relative to VEH (5.77 ± 0.0 kcal/h·kg). By wk 3, respiratory quotient no longer differed; however, EE increased with amylin treatment (5.74 ± 0.09 kcal/·kg; P < 0.05) relative to VEH (5.49 ± 0.06) and PF (5.38 ± 0.07 kcal/h·kg). Differences in EE, attributed to differences in lean mass, argued against specific amylin-induced thermogenesis. Weight loss in amylin and pair-fed rats was accompanied by similar increases arcuate neuropeptide Y mRNA (P < 0.05). Amylin treatment, but not PF, increased proopiomelanocortin mRNA levels (P < 0.05 vs. VEH). In a rodent model of obesity, amylin reduced body weight and body fat, with relative preservation of lean tissue, through anorexigenic and specific metabolic effects.
Copyright © 2006 by The Endocrine Society
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