Increased Expression of Angiogenic Genes in the Brains of Mouse Meg3-Null Embryos (original) (raw)

Journal Article

,

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

Search for other works by this author on:

,

2Molecular Pathology Unit (C.L.N., K.A.P.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129

Search for other works by this author on:

,

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

Search for other works by this author on:

,

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

Search for other works by this author on:

,

2Molecular Pathology Unit (C.L.N., K.A.P.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129

Search for other works by this author on:

,

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

Search for other works by this author on:

,

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

Search for other works by this author on:

,

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

Search for other works by this author on:

1Neuroendocrine Unit (F.E.G., P.C., Y.N., K.A.R., Y.Z., X.Z., A.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114

*Address all correspondence and requests for reprints to: Anne Klibanski, M.D., Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114.

Search for other works by this author on:

Received:

24 September 2009

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Francesca E. Gordon, Catherine L. Nutt, Pornsuk Cheunsuchon, Yuki Nakayama, Katelyn A. Provencher, Kimberley A. Rice, Yunli Zhou, Xun Zhang, Anne Klibanski, Increased Expression of Angiogenic Genes in the Brains of Mouse _Meg3_-Null Embryos, Endocrinology, Volume 151, Issue 6, 1 June 2010, Pages 2443–2452, https://doi.org/10.1210/en.2009-1151
Close

Navbar Search Filter Mobile Enter search term Search

Maternally expressed gene 3 (MEG3) is a noncoding RNA highly expressed in the normal human brain and pituitary. Expression of MEG3 is lost in gonadotroph-derived clinically nonfunctioning pituitary adenomas. Meg3 knockout mice were generated to identify targets and potential functions of this gene in embryonic development and tumorigenesis. Gene expression profiles were compared in the brains of _Meg3_-null embryos and wild-type littermate controls using microarray analysis. Microarray data were analyzed with GeneSifter, which uses Kyoto Encyclopedia of Genes and Genomes pathways and Gene Ontology classifications to identify signaling cascades and functional categories of interest within the dataset. Differences were found in signaling pathways and ontologies related to angiogenesis between wild-type and knockout embryos. Quantitative RT-PCR and immunohistological staining showed increased expression of some Vascular Endothelial Growth Factor pathway genes and increased cortical microvessel density in the _Meg3_-null embryos. In conclusion, Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis.

Copyright © 2010 by the Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Increased Expression of Angiogenic Genes in the Brains of Mouse _Meg3_-Null Embryos - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 2,200

1,510 Pageviews

690 PDF Downloads

Since 1/1/2017

Citations

143 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic