Cyclosporin-A in Vivo Produces Severe Osteopenia in the Rat: Effect of Dose and Duration of Administration* (original) (raw)
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Division of Endocrinology and Metabolism, Albert Einstein Medical Center, and the Department of Pathology and Laboratory Medicine, Surgical Pathology Section, Hospital of the University of Pennsylvania, University of Pennsylvania Medical School
Philadelphia, Pennsylvania 19141
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Division of Endocrinology and Metabolism, Albert Einstein Medical Center, and the Department of Pathology and Laboratory Medicine, Surgical Pathology Section, Hospital of the University of Pennsylvania, University of Pennsylvania Medical School
Philadelphia, Pennsylvania 19141
Search for other works by this author on:
,
1
Division of Endocrinology and Metabolism, Albert Einstein Medical Center, and the Department of Pathology and Laboratory Medicine, Surgical Pathology Section, Hospital of the University of Pennsylvania, University of Pennsylvania Medical School
Philadelphia, Pennsylvania 19141
Search for other works by this author on:
,
1
Division of Endocrinology and Metabolism, Albert Einstein Medical Center, and the Department of Pathology and Laboratory Medicine, Surgical Pathology Section, Hospital of the University of Pennsylvania, University of Pennsylvania Medical School
Philadelphia, Pennsylvania 19141
Search for other works by this author on:
1
Division of Endocrinology and Metabolism, Albert Einstein Medical Center, and the Department of Pathology and Laboratory Medicine, Surgical Pathology Section, Hospital of the University of Pennsylvania, University of Pennsylvania Medical School
Philadelphia, Pennsylvania 19141
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Published:
01 November 1988
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C. MOVSOWITZ, S. EPSTEIN, M. FALLON, F. ISMAIL, S. THOMAS, Cyclosporin-A in Vivo Produces Severe Osteopenia in the Rat: Effect of Dose and Duration of Administration, Endocrinology, Volume 123, Issue 5, 1 November 1988, Pages 2571–2577, https://doi.org/10.1210/endo-123-5-2571
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Cyclosporin-A (CsA) inhibits the in vitro boneresorbing effects of cytokines. We investigated the in vivo effects of CsA on rat bone mineral metabolism. Three groups of male Sprague-Dawley rats were administered vehicle or low dose (7.5 mg/kg) or high dose (15 mg/kg) CsA for 14 and 28 days. Ionized calcium, PTH, serum bone Gla protein, blood urea nitrogen, creatinine, magnesium, and 1,25-dihydroxyvitamin D were determined serially. No significant changes in calciotropic hormones or renal function were noted. Significant bone resorption and trabecular bone loss occurred in the high dose group by day 14 and in both groups by day 28. Bone Gla protein was significantly increased within 2 weeks in both dosage groups (P < 0.005), reflecting increased bone remodeling.
CsA in vivo resulted in an unexpected and significant increase in bone remodeling, with striking bone loss. These effects are dependent on the duration and dose of CsA and appear to be mediated at a local level. (Endocrinology123: 2571–2577,1988)
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Copyright © 1988 by The Endocrine Society
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