Hypocalcemic Effect of Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in the Thyroparathyroidectomized Rat (original) (raw)

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1Third Department of Internal Medicine, National Defense Medical College, Saitama (M.Y., T.M., M.N., T.A., K.M., N.N.), Japan

*Address all correspondence and requests for reprints to: Michiko Yamamoto, National Defense Medical College, Third Department of Internal Medicine, 3-2 Namiki, Tokorozawa, Saitama 359, Japan.

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1Third Department of Internal Medicine, National Defense Medical College, Saitama (M.Y., T.M., M.N., T.A., K.M., N.N.), Japan

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1Third Department of Internal Medicine, National Defense Medical College, Saitama (M.Y., T.M., M.N., T.A., K.M., N.N.), Japan

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2Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi (E.T., S.M., K.H.), Japan

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2Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi (E.T., S.M., K.H.), Japan

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2Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi (E.T., S.M., K.H.), Japan

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1Third Department of Internal Medicine, National Defense Medical College, Saitama (M.Y., T.M., M.N., T.A., K.M., N.N.), Japan

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1Third Department of Internal Medicine, National Defense Medical College, Saitama (M.Y., T.M., M.N., T.A., K.M., N.N.), Japan

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1Third Department of Internal Medicine, National Defense Medical College, Saitama (M.Y., T.M., M.N., T.A., K.M., N.N.), Japan

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Published:

01 September 1998

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Michiko Yamamoto, Takehiko Murakami, Miyuki Nishikawa, Eisuke Tsuda, Shin-Ichi Mochizuki, Kanji Higashio, Takuhiko Akatsu, Kazuo Motoyoshi, Naokazu Nagata, Hypocalcemic Effect of Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in the Thyroparathyroidectomized Rat, Endocrinology, Volume 139, Issue 9, 1 September 1998, Pages 4012–4015, https://doi.org/10.1210/endo.139.9.6290
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Abstract

Osteoclastogenesis inhibitory factor (OCIF), also termed as osteoprotegerin (OPG), is a soluble member of the tumor necrosis factor receptor family. Although OCIF/OPG is shown to inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo, its effect on serum calcium level remains to be determined. In this study we examined the acute effect of OCIF on thyroparathyroidectomized rats whose serum calcium concentrations were raised either by exogenous PTH or 1,25-(OH)-2D3. When OCIF was administered at the start of PTH infusion, it attenuated the initial rise in serum calcium. When OCIF was administered into rats with established hypercalcemia, it decreased serum calcium rapidly (within 2 hr) and dramatically. OCIF did not increase urinary calcium excretion. These findings, especially the rapid onset of its hypocalcemic effect, suggest that OCIF not only inhibits the formation of osteoclasts but also affects the function and/or survival of mature osteoclasts at doses used in this study.

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Copyright © 1998 by The Endocrine Society

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