Sensitivity of Fibroblast Growth Factor 23 Measurements in Tumor-Induced Osteomalacia (original) (raw)

Journal Article

,

2Pediatrics (E.A.I.), Indianapolis, Indiana 46202

Search for other works by this author on:

,

1Departments of Medicine (E.A.I., M.P., S.L.H., M.J.E.), Indianapolis, Indiana 46202

Search for other works by this author on:

,

4Childrens Hospital Los Angeles (P.P.), University of Southern California, Keck School of Medicine, Los Angeles, California 90027

Search for other works by this author on:

,

5University of Texas Southwestern Medical Center at Dallas (H.J.H.), Dallas, Texas 75390

Search for other works by this author on:

,

6Department of Pediatrics (L.M.W.), University of Ottawa, Ottawa, Ontario, Canada K1H 8L1

Search for other works by this author on:

,

7All Children’s Hospital (D.S.), University of South Florida College of Medicine, Tampa, Florida 33701

Search for other works by this author on:

,

8Department of Endocrinology (M.K.), University Hospital of Odense, DK-5000 Odense C, Denmark

Search for other works by this author on:

,

9Beth Israel Medical Center (P.R.), Albert Einstein School of Medicine, Bronx, New York 10003

Search for other works by this author on:

,

10Department of Veterans Affairs (M.Z.), New Jersey Health Care System, Lyons, New Jersey 07939

Search for other works by this author on:

,

11Department of Internal Medicine (A.D.), University of Virginia, Charlottesville, Virginia 22908

Search for other works by this author on:

... Show more

Received:

21 September 2005

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Erik A. Imel, Munro Peacock, Pisit Pitukcheewanont, Howard J. Heller, Leanne M. Ward, Dorothy Shulman, Moustapha Kassem, Paula Rackoff, Mark Zimering, Alan Dalkin, Elaine Drobny, Giacomo Colussi, Joseph L. Shaker, Elizabeth H. Hoogendoorn, Siu L. Hui, Michael J. Econs, Sensitivity of Fibroblast Growth Factor 23 Measurements in Tumor-Induced Osteomalacia, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 6, 1 June 2006, Pages 2055–2061, https://doi.org/10.1210/jc.2005-2105
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Context: Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome of hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum 1,25-dihydryxyvitamin-D concentration, myopathy, and osteomalacia. Fibroblast growth factor 23 (FGF23) is a phosphaturic protein overexpressed in tumors that cause TIO and is, at least partly, responsible for the manifestations of TIO.

Objective: The objective of this study was to determine the sensitivity of FGF23 measurements in TIO.

Design: FGF23 concentrations were measured on stored samples with three ELISAs.

Setting: This study was conducted at subspecialty referral centers.

Patients: Twenty-two patients with suspected TIO, 13 with confirmed tumors, were studied.

Interventions: There were no interventions in this study.

Main Outcome Measure: FGF23 concentration was the main outcome measure of this study.

Results: Elevated FGF23 concentrations were detected using the Immunotopics C-terminal assay in 16 of 22 TIO patients (for a sensitivity of 73%), the Immunotopics Intact assay in five of 22 patients (sensitivity, 23%), and the Kainos Intact assay in 19 of 22 patients (sensitivity, 86%). In the 13 patients with confirmed tumors, the sensitivity was higher with all assays: 92% for the Immunotopics C-terminal assay, 38% for the Immunotopics Intact assay, and 100% for the Kainos assay.

Conclusion: The Kainos Intact assay was the most sensitive, followed by the Immunotopics C-terminal assay. The findings of normal FGF23 concentrations in some patients with TIO may indicate that FGF 23 is not responsible for the hypophosphatemia in these patients or that FGF23 secretion by some tumors is partially responsive to serum phosphate. Normal FGF23 concentrations should be interpreted in relation to the serum phosphate and 1,25-dihydryxyvitamin-D concentrations.

Copyright © 2006 by The Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Sensitivity of Fibroblast Growth Factor 23 Measurements in Tumor-Induced Osteomalacia - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 1,758

1,279 Pageviews

479 PDF Downloads

Since 1/1/2017

Citations

182 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic