Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women (original) (raw)

Journal Article

,

1Endocrine Unit (J.S.F., R.M.N.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114

*Address all correspondence and requests for reprints to: Joel S. Finkelstein, M.D., Endocrine Unit, Thier 1051, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114.

Search for other works by this author on:

,

2Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Search for other works by this author on:

,

2Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Search for other works by this author on:

,

3Division of Geriatrics (G.A.G.), University of California, Los Angeles, School of Medicine, Los Angeles, California 90095

Search for other works by this author on:

,

4Departments of Epidemiology and Biostatistics (M.R.S.), School of Public Health, University of Michigan, Ann Arbor, Michigan 48109

Search for other works by this author on:

,

5Division of Research (B.E., J.C.L.), Kaiser Permanente Northern California, Oakland, California 94612

Search for other works by this author on:

,

5Division of Research (B.E., J.C.L.), Kaiser Permanente Northern California, Oakland, California 94612

Search for other works by this author on:

,

2Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Search for other works by this author on:

,

2Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Search for other works by this author on:

,

2Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Search for other works by this author on:

... Show more

Accepted:

19 December 2007

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Joel S. Finkelstein, Sarah E. Brockwell, Vinay Mehta, Gail A. Greendale, MaryFran R. Sowers, Bruce Ettinger, Joan C. Lo, Janet M. Johnston, Jane A. Cauley, Michelle E. Danielson, Robert M. Neer, Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women, The Journal of Clinical Endocrinology & Metabolism, Volume 93, Issue 3, 1 March 2008, Pages 861–868, https://doi.org/10.1210/jc.2007-1876
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Context: Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood.

Objective: Our objective was to assess rates of bone loss at each stage of the transition and examine major factors that modify those rates.

Design, Setting, and Participants: We conducted a longitudinal cohort study of 1902 African-American, Caucasian, Chinese, or Japanese women participating in The Study of Women’s Health Across the Nation. Women were pre- or early perimenopausal at baseline.

Outcome Measure: We assessed bone mineral density (BMD) of the lumbar spine and total hip across a maximum of six annual visits.

Results: There was little change in BMD during the pre- or early perimenopause. BMD declined substantially in the late perimenopause, with an average loss of 0.018 and 0.010 g/cm2·yr from the spine and hip, respectively (P < 0.001 for both). In the postmenopause, rates of loss from the spine and hip were 0.022 and 0.013 g/cm2·yr, respectively (P < 0.001 for both). During the late peri- and postmenopause, bone loss was approximately 35–55% slower in women in the top vs. the bottom tertile of body weight. Apparent ethnic differences in rates of spine bone loss were largely explained by differences in body weight.

Conclusions: Bone loss accelerates substantially in the late perimenopause and continues at a similar pace in the first postmenopausal years. Body weight is a major determinant of the rate of menopausal BMD loss, whereas ethnicity, per se, is not. Healthcare providers should consider this information when deciding when to screen women for osteoporosis.

Copyright © 2008 by The Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 6,770

4,751 Pageviews

2,019 PDF Downloads

Since 1/1/2017

Citations

401 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic