Glucagon Like Peptide-1 Receptor Expression in the Human Thyroid Gland (original) (raw)
Journal Article
1Larry L. Hillblom Islet Research Center (B.G., P.C.B., D.K.), Los Angeles, California 90095-6904
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1Larry L. Hillblom Islet Research Center (B.G., P.C.B., D.K.), Los Angeles, California 90095-6904
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2Department of Pathology and Laboratory Medicine (C.K.L., M.M.D.), Los Angeles, California 90095-6904
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1Larry L. Hillblom Islet Research Center (B.G., P.C.B., D.K.), Los Angeles, California 90095-6904
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2Department of Pathology and Laboratory Medicine (C.K.L., M.M.D.), Los Angeles, California 90095-6904
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3Section of Endocrine Surgery (M.W.Y.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095-6904
*Address all correspondence and requests for reprints to: Michael W. Yeh, M.D., F.A.C.S., Section of Endocrine Surgery, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue 72-228 CHS, Los Angeles, California 90095-6904.
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Accepted:
26 September 2011
Published:
01 January 2012
Cite
Belinda Gier, Peter C. Butler, Chi K. Lai, David Kirakossian, Matthew M. DeNicola, Michael W. Yeh, Glucagon Like Peptide-1 Receptor Expression in the Human Thyroid Gland, The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 1, 1 January 2012, Pages 121–131, https://doi.org/10.1210/jc.2011-2407
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Background:
Glucagon like peptide-1 (GLP-1) mimetic therapy induces medullary thyroid neoplasia in rodents. We sought to establish whether C cells in human medullary thyroid carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor.
Methods:
Thyroid tissue samples with medullary thyroid carcinoma (n = 12), C cell hyperplasia (n = 9), papillary thyroid carcinoma (n = 17), and normal human thyroid (n = 15) were evaluated by immunofluorescence for expression of calcitonin and GLP-1 receptors.
Results:
Coincident immunoreactivity for calcitonin and GLP-1 receptor was consistently observed in both medullary thyroid carcinoma and C cell hyperplasia. GLP-1 receptor immunoreactivity was also detected in 18% of papillary thyroid carcinoma (three of 17 cases). Within normal human thyroid tissue, GLP-1 receptor immunoreactivity was found in five of 15 of the examined cases in about 35% of the total C cells assessed.
Conclusions:
In humans, neoplastic and hyperplastic lesions of thyroid C cells express the GLP-1 receptor. GLP-1 receptor expression is detected in 18% papillary thyroid carcinomas and in C cells in 33% of control thyroid lobes. The consequence of long-term pharmacologically increased GLP-1 signaling on these GLP-1 receptor-expressing cells in the thyroid gland in humans remains unknown, but appropriately powered prospective studies to exclude an increase in medullary or papillary carcinomas of the thyroid are warranted.
Copyright © 2012 by The Endocrine Society
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