The Association Between Perchlorate and Thiocyanate Exposure and Thyroid Function in First-Trimester Pregnant Thai Women (original) (raw)

Journal Article

,

Natthinee Charatcharoenwitthaya

1Departments of Medicine (N.C.), Pathumthani 10200, Thailand

Search for other works by this author on:

,

Boonsong Ongphiphadhanakul

3Department of Medicine (B.O., L.C.), Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Search for other works by this author on:

,

4Department of Medicine (E.N.P., X.H., L.E.B.), Boston University School of Medicine, Boston, Massachusetts 02118-2308

Search for other works by this author on:

,

2Obstetrics and Gynecology (C.S., A.C.), Faculty of Medicine, Thammasat University, Pathumthani 10200, Thailand

Search for other works by this author on:

,

2Obstetrics and Gynecology (C.S., A.C.), Faculty of Medicine, Thammasat University, Pathumthani 10200, Thailand

Search for other works by this author on:

,

4Department of Medicine (E.N.P., X.H., L.E.B.), Boston University School of Medicine, Boston, Massachusetts 02118-2308

Search for other works by this author on:

,

3Department of Medicine (B.O., L.C.), Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Search for other works by this author on:

4Department of Medicine (E.N.P., X.H., L.E.B.), Boston University School of Medicine, Boston, Massachusetts 02118-2308

*Address all correspondence and requests for reprints to: Lewis E. Braverman, MD, Departments of Endocrinology and Diabetes and Nutrition, Boston University School of Medicine, Evans Building, Room 201, 88 East Newton Street, Boston, MA 02118-2308.

Search for other works by this author on:

Received:

04 November 2013

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Natthinee Charatcharoenwitthaya, Boonsong Ongphiphadhanakul, Elizabeth N. Pearce, Charintip Somprasit, Athita Chanthasenanont, Xuemei He, Laor Chailurkit, Lewis E. Braverman, The Association Between Perchlorate and Thiocyanate Exposure and Thyroid Function in First-Trimester Pregnant Thai Women, The Journal of Clinical Endocrinology & Metabolism, Volume 99, Issue 7, 1 July 2014, Pages 2365–2371, https://doi.org/10.1210/jc.2013-3986
Close

Navbar Search Filter Mobile Enter search term Search

Context:

Thyroid hormone is critical for fetal neurodevelopment. Perchlorate and thiocyanate decrease thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is clear that perchlorate and thiocyanate anions can influence thyroid function. However, as pollutants in the environment, their impact is conflicting.

Objective:

The objective was to determine the effects of environmental perchlorate and/or thiocyanate exposure on thyroid function in first-trimester pregnant women.

Design and Patients:

A cross-sectional study was conducted in 200 pregnant Thai women with a gestational age of 14 weeks or less.

Measures:

Urinary iodide, perchlorate, thiocyanate, and serum thyroid function tests were measured.

Results:

The women were aged 28.6 ± 6.1 years and the mean gestational age was 9.6 ± 2.7 weeks. Median urinary iodide, perchlorate, and thiocyanate concentrations were 153.5 μg/L, 1.9 μg/L, and 510.5 μg/L, respectively. Using Spearman's rank correlation analyses, there were positive correlations between serum TSH and urine perchlorate to creatinine (r = 0.20, P = .005) and TSH and thiocyanate to creatinine ratios (r = 0.22, P = .001). There were negative correlations between free T4 and the perchlorate to creatinine ratio (r = −0.18, P = .01) and free T4 and the thiocyanate to creatinine ratio (r = −0.19, P = .008). In multivariate analyses adjusting for log thiocyanate to creatinine ratio, log iodide to creatinine ratio, and gestational age, log perchlorate to creatinine ratio was positively associated with log TSH (P = .002) and inversely associated with log free T4 (P = .002). Log thiocyanate to creatinine ratio was a significant positive predictor of log TSH (P = .02) in women with a urine iodide level of less than 100 μg/L.

Conclusions:

Low-level environmental exposure to perchlorate and thiocyanate is common in Thailand. Low-level exposure to perchlorate is positively associated with TSH and negatively associated with free T4 in first-trimester pregnant women using multivariate analyses. In multivariate analyses, thiocyanate exposure is also positively associated with TSH in a subgroup of pregnant women with low iodine excretion.

Copyright © 2014 by the Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

The Association Between Perchlorate and Thiocyanate Exposure and Thyroid Function in First-Trimester Pregnant Thai Women - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 1,606

1,107 Pageviews

499 PDF Downloads

Since 1/1/2017

Citations

31 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic