Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1 (original) (raw)

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1Center for Biotechnology (E.E.), S-141 57 Huddinge, Sweden;

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2Department of Medical Nutrition (M.P-H., K.G., J-Å.G.), Novum, S-141 57 Huddinge, Sweden;

4Department of Anatomy (M.P-H.), Tampere, Finland;

5Medical School, University of Tampere and Department of Pathology (M.P-H.), Tampere University Hospital, Tampere, Finland;

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2Department of Medical Nutrition (M.P-H., K.G., J-Å.G.), Novum, S-141 57 Huddinge, Sweden;

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3Department of Molecular Medicine (S.L., J.L., M.N.), Karolinska Hospital, CMM, L8:01 and L8:02, S-171 76 Stockholm, Sweden;

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3Department of Molecular Medicine (S.L., J.L., M.N.), Karolinska Hospital, CMM, L8:01 and L8:02, S-171 76 Stockholm, Sweden;

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6Department of Physiology and Pharmacology (G.F.), S-171 77 Stockholm, Sweden

7Karolinska Institute and Department of Woman and Child Health (G.F.), Karolinska Hospital, S-171 77 Stockholm, Sweden

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3Department of Molecular Medicine (S.L., J.L., M.N.), Karolinska Hospital, CMM, L8:01 and L8:02, S-171 76 Stockholm, Sweden;

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2Department of Medical Nutrition (M.P-H., K.G., J-Å.G.), Novum, S-141 57 Huddinge, Sweden;

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Revision received:

17 September 1997

Accepted:

19 September 1997

Published:

01 December 1997

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Eva Enmark, Markku Pelto-Huikko, Kaj Grandien, Svetlana Lagercrantz, Jacob Lagercrantz, Gabriel Fried, Magnus Nordenskjöld, Jan-Åke Gustafsson, Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern, The Journal of Clinical Endocrinology & Metabolism, Volume 82, Issue 12, 1 December 1997, Pages 4258–4265, https://doi.org/10.1210/jcem.82.12.4470
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The estrogen receptor (ER) is a ligand-activated transcription factor that mediates the effects of the steroid hormone 17β-estradiol, in both males and females. Since the isolation and cloning of ER, the consensus has been that only one such receptor exists.

The finding of a second subtype of ER (ERβ) has caused considerable excitement amongst endocrinologists. In this article, we present data regarding the genomic structure and chromosomal localization of the human ERβ gene, demonstrating that two independent ER genes do exist in the human. Furthermore, we present data regarding the tissue distribution of human ERβ, showing that this receptor is expressed in multiple tissues. For instance, ERβ is found in developing spermatids of the testis, a finding of potential relevance for the ongoing debate on the effects of environmental estrogens on sperm counts. In addition, we find ERβ in ovarian granulosa cells, indicating that estrogens also participate in the regulation of follicular growth in the human.

Copyright © 1997 by The Endocrine Society

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