Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones (original) (raw)

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1Columbia University (M.R., E.M.M., S.B.H., R.L.L.), New York, New York

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1Columbia University (M.R., E.M.M., S.B.H., R.L.L.), New York, New York

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1Columbia University (M.R., E.M.M., S.B.H., R.L.L.), New York, New York

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2University of Vermont Medical Center (D.E.M.), Burlington, Vermont

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1Columbia University (M.R., E.M.M., S.B.H., R.L.L.), New York, New York

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Michael Rosenbaum, Ellen M. Murphy, Steven B. Heymsfield, Dwight E. Matthews, Rudolph L. Leibel, Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones, The Journal of Clinical Endocrinology & Metabolism, Volume 87, Issue 5, 1 May 2002, Pages 2391–2394, https://doi.org/10.1210/jcem.87.5.8628
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Maintenance of a reduced body weight is associated with decreased 24-hour energy expenditure, and decreased circulating concentrations of leptin and thyroid hormones. To determine whether these adaptive metabolic and endocrine changes are partly leptin-mediated, we measured body composition, aspects of energy expenditure, and circulating concentrations of leptin and thyroid hormones in 4 subjects at 3 time points: 1.) Usual body weight; 2.) While stable at 10% reduced body weight; and 3.) During a 5-week period at 10% reduced body weight while receiving twice per day leptin injections that restored 8 AM circulating leptin concentrations to those seen at usual body weight. During maintenance of a 10% reduced body weight, circulating T3, T4, and leptin concentrations were decreased. All of these endocrine changes were reversed by administration of “replacement” doses of leptin (r-metHuLeptin). Indirect calorimetry, and subtle changes in body composition associated with leptin administration, were used to calculate the net change in stored calories and in 24-hour energy expenditure. Total energy expenditure increased in all subjects during r-metHuLeptin administration. These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state.

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Copyright © 2002 by The Endocrine Society

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