MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model (original) (raw)
Journal Article
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1Department of Pharmacology, Division of Molecular Endocrinology, New York University Medical Center New York, New York 10016; Department of Medicine, Division of Molecular Endocrinology, New York University Medical Center New York, New York 10016
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1Department of Pharmacology, Division of Molecular Endocrinology, New York University Medical Center New York, New York 10016; Department of Medicine, Division of Molecular Endocrinology, New York University Medical Center New York, New York 10016
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This work was supported by a Medical Scientist Training Program grant (to B.M.F.) and NIH research Grant DK-16636 (to H.H.S.).
Published:
01 September 1990
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Barry Marc Forman, Herbert H. Samuels, MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model, Molecular Endocrinology, Volume 4, Issue 9, 1 September 1990, Pages 1293–1301, https://doi.org/10.1210/mend-4-9-1293
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Abstract
The nuclear hormone receptors comprise a super-family of ligand-modulated transcription factors that regulate homeostasis, reproduction, development, and differentiation. Three amino acids within the zinc finger DNA binding motif determine target gene specificity. Groups of receptors exist with similar DNA binding specificity. A complex carboxy terminal region mediates ligand binding, dimerization, and hormone-relieved transcriptional inactivation. We summarize the current understanding of these phenomena and suggest a novel model that structurally and functionally links these events. This “regulatory zipper model” may explain the mechanism by which ligand activates nuclear hormone receptors.
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Author notes
This work was supported by a Medical Scientist Training Program grant (to B.M.F.) and NIH research Grant DK-16636 (to H.H.S.).
Copyright © 1990 by The Endocrine Society
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